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Table 5 Bone remodeling signature

From: Insights in to the pathogenesis of axial spondyloarthropathy based on gene expression profiles

   Set 1 Set 2  
Gene symbol Gene name Fold change Q (%) Fold change Q (%) Function
BMP6 Bone morphogenetic protein 6 1.5 2.4 1.7 1.5 Involved in ossification, osteoblast differentiation
CTNNAL1* Catenin (cadherin-associated protein), alpha-like 1 3.0 2.3 2.3 2.1 Analogous to α-catenin which inhibits β-catenin. Á catenin inhibits wnt/catenin pathway
KREMEN1 Kringle containing transmembrane protein 1 2.0 2.4 2.0 2.5 Negative regulator of wnt/catenin pathway
PCSK6 Proprotein convertase subtilisin/kexin type 6 3.1 2.4 2.0 1.8 Regulator of BMP6
  1. *Secondary analysis indicates that expression level changes are more apparent in males.