Table 5 Bone remodeling signature
From: Insights in to the pathogenesis of axial spondyloarthropathy based on gene expression profiles
Set 1 | Set 2 | |||||
|---|---|---|---|---|---|---|
Gene symbol | Gene name | Fold change | Q (%) | Fold change | Q (%) | Function |
BMP6 | Bone morphogenetic protein 6 | 1.5 | 2.4 | 1.7 | 1.5 | Involved in ossification, osteoblast differentiation |
CTNNAL1* | Catenin (cadherin-associated protein), alpha-like 1 | 3.0 | 2.3 | 2.3 | 2.1 | Analogous to α-catenin which inhibits β-catenin. Á catenin inhibits wnt/catenin pathway |
KREMEN1 | Kringle containing transmembrane protein 1 | 2.0 | 2.4 | 2.0 | 2.5 | Negative regulator of wnt/catenin pathway |
PCSK6 | Proprotein convertase subtilisin/kexin type 6 | 3.1 | 2.4 | 2.0 | 1.8 | Regulator of BMP6 |