Figure 3
From: Influence of cytokine inhibitors on concentration and activity of MMP-1 and MMP-3 in disc herniation
Effect of IL-1Ra, dexamethasone and TNF inhibitor on matrix metalloproteinase-1. Dexamethasone significantly inhibits both (a) total matrix metalloproteinase (MMP)-1 activity and (b) active MMP-1 without modifying levels of (c) pro-MMP-1. No effect was observed for IL-1Ra and TNF inhibitor. Line in center box, median; lower and upper borders of boxes, lower (Q1) and upper (Q3) quartiles; whiskers, minimum and maximum values; o, outliers (values exceeding 1.5 × (Q3 - Q1)).