Spydergram of SF-36 domains at baseline and weeks 12 and 52 (ITT population, LOCF). Physical domains: Physical Function (PF), Role Physical (RP), Bodily Pain (BP), General Health (GH). Mental domains: Vitality (VT), Social Function (SF), Role Emotional (RE), Mental Health (MH). Domain scores are plotted from 0 (worst) at the center to 100 (best) at the outside; demarcations along axes of the domains present changes of 10 points, representing 1 - 2 times MCID. As the RAPID 1 protocol included RA subjects recruited outside North America, available US normative data offer a 'benchmark', but less realistic goal for therapy. Changes from baseline for all SF-36 domains were statistically significant for CZP versus PBO at Weeks 12 and 52; P < 0.05. CZP = certolizumab pegol; ITT = intent to treat; LOCF = last observation carried forward; MCID = minimal clinically important difference; PBO = placebo; RA = rheumatoid arthritis; RAPID 1 = RA PreventIon of Structural Damage 1; SF-36 = short-form 36-item health survey.