Table 1 Baseline disease activity and PRO scores (ITT population)
Characteristic, mean (SD) | CZP 200 mg + MTX (n = 393) | CZP 400 mg + MTX (n = 390) | PBO + MTX (n = 199) |
|---|---|---|---|
DAS28, range 0-10 | 6.9 (0.8) | 6.9 (0.8) | 7.0 (0.9) |
PtGA VAS, range 0-100 mm | 63.1 (20.3) | 64.1 (18.3) | 64.2 (19.6) |
Pain VAS, range 0-100 mm | 62.1 (20.0) | 63.8 (17.2) | 63.6 (19.9) |
HAQ-DI, range 0-3 | 1.7 (0.6) | 1.7 (0.6) | 1.7 (0.6) |
Fatigue NRS, range 0-10 | 6.4 (2.0) | 6.5 (1.9) | 6.7 (2.0) |
SF-36 | |||
PCS, range 0-100* | 30.9 (6.5) | 30.8 (6.8) | 30.5 (5.8) |
MCS, range 0-100* | 40.0 (11.2) | 39.3 (11.1) | 38.6 (11.4) |
Domains, range 0-100 | |||
Physical Functioning | 33.4 (21.4) | 32.9 (21.2) | 32.0 (20.1) |
Role Physical | 13.3 (23.7) | 12.9 (25.4) | 11.2 (20.8) |
Bodily Pain | 30.6 (15.3) | 28.9 (15.9) | 28.5 (14.7) |
General Health | 35.3 (16.5) | 35.9 (17.5) | 34.9 (15.6) |
Vitality | 35.8 (18.0) | 36.1 (18.6) | 32.9 (17.4) |
Social Functioning | 50.9 (23.8) | 48.1 (24.0) | 46.6 (25.2) |
Role Emotional | 32.4 (39.1) | 28.9 (38.1) | 30.9 (38.7) |
Mental Health | 53.8 (20.1) | 53.5 (20.7) | 52.2 (21.2) |