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Table 1 Allele frequencies and Cochrane-Armitage test for trend of genotype distribution in patients with AS and HLA-B27-matched controls in Sardinia

From: HLA-E gene polymorphism associates with ankylosing spondylitis in Sardinia

    HLA-B27+ controls n = 175 HLA-B27+ patients with AS n = 120    
Gene SNP Position on chromosome 6 MAF (%) MAF (%) P OR (95% CI)
RANP1 rs2105960 30561768 245 (75) 154 (69) ns   
  TT   94 (57) 49 (44)    
  CT   63 (38) 56 (50)    
  CC   9 (5) 7 (6)    
  P trend     ns   
HLA-E rs1264457 30566040 207 (59) 177 (74) 1 × 10-4 2 1.4-2.9
  AA   51 (29) 61 (51) Ref   
  AG   105 (60) 55 (46) 1 × 10-3 0.44 (0.27-0.72)
  GG   19 (11) 3 (3) 4 × 10-4 0.13 (0.04-0.5)
  P trend     5 × 10 -5   
GNL1 rs2074505 30629116 219 (63) 179 (76) 4 × 10-4 1.9 1.4-2.8
  AA   68 (39) 68 (58) Ref   
  AG   83 (47) 43 (37) 0.01 0.52 (0.31-0.85)
  GG   24 (14) 6 (5) 4 × 10-3 0.25 (0.1-0.65)
  P trend     4 × 10 -4   
PRR3 rs2074503 30638475 247 (76) 203 (85) 9 × 10-3 1.8 1.2-2.7
  GG   93 (57) 85 (71) Ref   
  AG   61 (37) 33 (28) 0.05 0.59 (0.35-1)
  AA   10 (6) 2 (1) 0.04 0.22 (0.05-1)
  P trend     7 × 10 -3   
ABCF1 rs2269709 30648869 224 (74) 201 (84) 5 × 10-3 1.8 1.2-2.8
  AA   82 (54) 83 (69) Ref   
  AG   60 (39) 35 (29) 0.04 0.58 (0.34-0.99)
  GG   10 (7) 2 (2) 0.03 0.2 (0.04-0-9)
  P trend     4 × 10 -3   
ABCF1 rs1264439 30660481 312 (91) 212 (91) ns   
  GG   142 (83) 97 (84)    
  GT   28 (16) 18 (15)    
  TT   1 (1) 1 (1)    
  P trend     ns   
  1. AS = ankylosing spondylitis; CI = confidence interval; MAF = major allele frequency; ns = not significant; OR = odds ratio; SNP = single nucleotide polymorphism.