Table 1 Allele frequencies and Cochrane-Armitage test for trend of genotype distribution in patients with AS and HLA-B27-matched controls in Sardinia
From: HLA-E gene polymorphism associates with ankylosing spondylitis in Sardinia
HLA-B27+ controls n = 175 | HLA-B27+ patients with AS n = 120 | ||||||
|---|---|---|---|---|---|---|---|
Gene | SNP | Position on chromosome 6 | MAF (%) | MAF (%) | P | OR | (95% CI) |
RANP1 | rs2105960 | 30561768 | 245 (75) | 154 (69) | ns | ||
TT | 94 (57) | 49 (44) | |||||
CT | 63 (38) | 56 (50) | |||||
CC | 9 (5) | 7 (6) | |||||
P trend | ns | ||||||
HLA-E | rs1264457 | 30566040 | 207 (59) | 177 (74) | 1 × 10-4 | 2 | 1.4-2.9 |
AA | 51 (29) | 61 (51) | Ref | ||||
AG | 105 (60) | 55 (46) | 1 × 10-3 | 0.44 | (0.27-0.72) | ||
GG | 19 (11) | 3 (3) | 4 × 10-4 | 0.13 | (0.04-0.5) | ||
P trend | 5 × 10 -5 | ||||||
GNL1 | rs2074505 | 30629116 | 219 (63) | 179 (76) | 4 × 10-4 | 1.9 | 1.4-2.8 |
AA | 68 (39) | 68 (58) | Ref | ||||
AG | 83 (47) | 43 (37) | 0.01 | 0.52 | (0.31-0.85) | ||
GG | 24 (14) | 6 (5) | 4 × 10-3 | 0.25 | (0.1-0.65) | ||
P trend | 4 × 10 -4 | ||||||
PRR3 | rs2074503 | 30638475 | 247 (76) | 203 (85) | 9 × 10-3 | 1.8 | 1.2-2.7 |
GG | 93 (57) | 85 (71) | Ref | ||||
AG | 61 (37) | 33 (28) | 0.05 | 0.59 | (0.35-1) | ||
AA | 10 (6) | 2 (1) | 0.04 | 0.22 | (0.05-1) | ||
P trend | 7 × 10 -3 | ||||||
ABCF1 | rs2269709 | 30648869 | 224 (74) | 201 (84) | 5 × 10-3 | 1.8 | 1.2-2.8 |
AA | 82 (54) | 83 (69) | Ref | ||||
AG | 60 (39) | 35 (29) | 0.04 | 0.58 | (0.34-0.99) | ||
GG | 10 (7) | 2 (2) | 0.03 | 0.2 | (0.04-0-9) | ||
P trend | 4 × 10 -3 | ||||||
ABCF1 | rs1264439 | 30660481 | 312 (91) | 212 (91) | ns | ||
GG | 142 (83) | 97 (84) | |||||
GT | 28 (16) | 18 (15) | |||||
TT | 1 (1) | 1 (1) | |||||
P trend | ns |