HLA-E gene polymorphism associates with ankylosing spondylitis in Sardinia

Table 2 Haplotype distribution in patients with AS and controls

Haplotypes rs1264457/rs2074505/rs2074503/rs2269709	Random controls	HLA-B27 controls		P	HLA-B27 patients with AS	p1	p2
		Non B2709 (B2709) n = 135	n = 40
AAGA	0.42	0.52	(0.59)*	9 × 10^-4	0.68	2 × 10^-11	3 × 10^-4
GGAG	0.24	0.23	(0.16)	ns	0.12	1 × 10^-4	0.001
GGGA	0.14	0.10	(0.10)	ns	0.05	7 × 10^-4	ns
Others	0.20	0.15	(0.15)	ns	0.15	ns	ns

in brackets = haplotype frequencies referring to 40 HLA-B*2709 positive subjects which had been enclosed in the statistical analysis; p1 = HLA-B27 positive patients with AS vs random controls; p2 = HLA-B27 positive patients with AS vs the pool of the HLA-B27 positive controls. AS = ankylosing spondylitis.

ISSN: 1478-6362