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Figure 2 | Arthritis Research & Therapy

Figure 2

From: Intradiscal injection of simvastatin retards progression of intervertebral disc degeneration induced by stab injury

Figure 2

mRNA expression of (a) aggrecan, (b) type II collagen, (c) type I collagen, and (d) differentiation index in the nucleus pulpous of different experimental groups at two weeks after drug injection. The differentiation index is the ratio of type II to type I collagens. Discs in the treatment groups were injected with either 2 μL of gel alone or gel loaded with simvastatin (SIM; 5 mg/mL) at four weeks after the disc stab with 21-G needle. * P < 0.05 and ** P < 0.01 when compared with intact control group;# P < 0.05 and ## P < 0.01 when compared with stabbed group; + P < 0.05 and ++ P < 0.01 when compared with gel-alone-treated group.

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