Figure 6

Inhibition of IL-1-induced collagen (a) release to media and (b) loss from immature middle-zone meniscal explants by metalloproteinase inhibitors. Data are mean ± standard error of the mean with n = 6. †, ‡, and # indicate P < 0.05 vs. IL-1 for untreated, IL-1 + matrix metalloproteinase (MMP) inhibitors, and IL-1 + broad-spectrum inhibitors, respectively.