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Figure 3 | Arthritis Research & Therapy

Figure 3

From: CTLA4-Ig interacts with cultured synovial macrophages from rheumatoid arthritis patients and downregulates cytokine production

Figure 3

Immunocytochemistry for IL-6, TNFα, IL-1β and TGFβ expression in co-cultures of macrophage/Jurkat. Immunocytochemistry in co-cultures of macrophage/Jurkat, (a) untreated (controls) and (a1) treated with CTLA4-Ig 500 μg/ml for IL-6, (b) untreated (controls) and (b1) treated with TNFalpha, (c) untreated (controls) and (c1) treated with IL-1β and (d) untreated (controls) and (d1) treated with TGFβ. Quantification (mean value ± standard deviation) of immunocytochemistry (ICC-QWin) for (e) IL-6, (f) TNFα, (g) IL-1β and (h) TGFβ expression in co-cultures of macrophage/Jurkat, untreated (controls) and treated with CTLA4-Ig (10, 100, 500 μg/ml). * P < 0.05; ** P < 0.01; *** P < 0.001.

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