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Table 4 Comparison of adverse events between the chicken type II collagen group and the methotrexate group at 12 and 24 weeks

From: A multicenter, double-blind, randomized, controlled phase III clinical trial of chicken type II collagen in rheumatoid arthritis

Weeks Groups Adverse events Rate of adverse events Chi-square Pvaluea
12 CCII (n = 326) 18 5.52% 1.974 0.048
  MTX (n = 177) 15 8.47%   
24 CCII (n = 326) 18 5.52% 2.001 0.036
  MTX (n = 177) 17 9.60%   
  1. aShowed chi-square test. CCII, chicken type II collagen; MTX, methotrexate.