Figure 2From: A combination of methotrexate and zoledronic acid prevents bone erosions and systemic bone mass loss in collagen induced arthritisRepresentative plain radiographs of the hind paws obtained at the end of the experiment. The (a) control, (b) methotrexate (MTX), (c) zoledronic acid (ZA), and (d) ZA + MTX groups are shown. Severe loss of subchondral bone was seen in the control group, with multiple areas of erosion, whereas lower levels of destruction were observed in MTX-treated rats. ZA completely prevented bone destruction. (e) Soft-tissue swelling and erosion radiographic score for the ankle and tarsus joints. ZA alone or in combination with MTX significantly decreased the erosion score, but had a pro-inflammatory effect, increasing soft-tissue swelling. MTX also decreased the number of areas of erosion and decreased the soft-tissue swelling. *P < 0.05 versus computed tomography (CT) group.Back to article page