Skip to main content
Figure 3 | Arthritis Research & Therapy

Figure 3

From: RANKL inhibition by osteoprotegerin prevents bone loss without affecting local or systemic inflammation parameters in two rat arthritis models: comparison with anti-TNFα or anti-IL-1 therapies

Figure 3

Effect of anti-TNFα, anti-IL-1, or anti-RANKL therapy on bone mineral density. Effects of PEGylated soluble TNF receptor type I (TNFRI), IL-1 receptor antagonist (IL-1Ra) or osteoprotegerin (OPG)-Fc on areal bone mineral density (BMD) of the (a), (b) ankle and (c), (d) lumbar vertebrae. Baseline BMD measures were obtained by dual X-ray absorptiometry on the day of onset for clinical arthritis (day 0). Treatments were initiated on day 4, and final BMD was measured on day 14 post onset. Data represent means ± standard error of the means, n = 8/group. cSignificantly different from control (nonarthritic) rats, P < 0.05. vSignificantly different from vehicle (Veh)-treated arthritic rats, P < 0.05. oSignificantly different from OPG-treated arthritic rats, P < 0.05. AIA, adjuvant-induced arthritis; CIA, collagen-induced arthritis.

Back to article page

Arthritis Research & Therapy

ISSN: 1478-6362

Contact us