TY - JOUR AU - Vosters, Jelle L. AU - Yin, Hongen AU - Roescher, Nienke AU - Kok, Marc R. AU - Tak, Paul P. AU - Chiorini, John A. PY - 2009 DA - 2009/12/14 TI - Local expression of tumor necrosis factor-receptor 1:immunoglobulin G can induce salivary gland dysfunction in a murine model of Sjögren's syndrome JO - Arthritis Research & Therapy SP - R189 VL - 11 IS - 6 AB - Tumor necrosis factor is a pleiotropic cytokine with potent immune regulatory functions. Although tumor necrosis factor inhibitors have demonstrated great utility in treating other autoimmune diseases, such as rheumatoid arthritis, there are conflicting results in Sjögren's syndrome. The aim of this study was to assess the effect of a locally expressed tumor necrosis factor inhibitor on the salivary gland function and histopathology in an animal model of Sjögren's syndrome. SN - 1478-6354 UR - https://doi.org/10.1186/ar2888 DO - 10.1186/ar2888 ID - Vosters2009 ER -