Figure 2

Diabetes, saliva flow, and body weight in untreated and vector treated groups. A) Blood sugar was monitored starting at week 13 (five weeks post vector delivery) as described in the Materials and Methods section. Data shown are the mean percentage from two independent experiments (N = 8 for untreated, N = 20 for LacZ and N = 19 for TNFR1:IgG). B) Saliva was collected as described in the Materials and Methods section over a 20-minute period after stimulation with 0.5 mg/kg BW pilocarpine. Data shown are mean values +/- SEM (N = 8 for untreated, N = 20 for LacZ and N = 19 for TNFR1:IgG). P-values are indicated and were determined by non-parametric Wilcoxon's ranksum test. Delivery of TNFR1:IgG resulted in significant decreased saliva flow not seen in control groups. C) The weight of the mice (in grams) was measured at the indicate times for LacZ, TNFR1:IgG, and untreated mice. There were no significant changes in bodyweight between all three groups as determined by unpaired student's t-test. Data shown are the mean (+/- SD) of two independent experiments (N = 8 for untreated, N = 11 for LacZ and N = 12 for TNFR1:IgG per experiment).