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Table 2 Cytokines in salivary gland extract and plasma

From: Local expression of tumor necrosis factor-receptor 1:immunoglobulin G can induce salivary gland dysfunction in a murine model of Sjögren's syndrome

  Salivary gland extract
(pg/ml per 20 mg wet SG)
Plasma (pg/ml)
  LacZ TNFR1:IgG Pvalue LacZ TNFR1:IgG Pvalue
mTNF-α 73.0 (53.0) 24.6 (2.5) 0.9273 21.2 (5.3) 45.5 (15.3) 0.3152
MCP-1 325.0 (222.7) 254.6 (70.6) 1.0000 182.0 (49.0) 95.1 (10.8) 0.0727
mIL-4 23.0 (12.2) 3.8 (1.0) 0.0727 1.2 (0.05) 16.1 (2.3) *0.0061
mIL-5 94.5 (41.4) 7.3 (1.9) *0.0061 2.3 (0.04) 30.7 (8.3) 0.0727
mIL-6 109.9 (61.4) 42.4 (15.2) 0.3152 20.7 (8.8) 37.0 (5.7) 0.1636
mIFN-γ 657.9 (305.5) 614.9 (216.1) 0.5273 192.9 (28.5) 511.7 (75.0) *0.0061
mIL-10 37.6 (14.8) 7.7 (2.0) 0.0727 3.0 (0.4) 27.5 (3.3) *0.0061
mTGF-β1 4342 (1742) 3.0E6 (7.8E5) *0.0061 7.8E5 (8.1E4) 1840 (187.7) *0.0061
mIL-12p70 130.2 (54.3) 6.3 (2.3) *0.0061 18.3 (11.0) 65.8 (7.4) *0.0242
mIL-17 53.2 (24.3) 5.4 (1.6) *0.0242 6.4 (3.1) 12.1 (1.8) 0.1636
hTNFR1 0.0 (0.0) 114.4 (43.5) ND    
  1. Protein expression of immunomodulatory molecules after administration of LacZ and TNFR1:IgG in salivary gland extract and plasma. Data shown are mean values +/- SEM. Significant differences are indicated (*) and were determined by non-parametric Wilcoxon's ranksum test. LacZ (N = 4) and TNFR1:IgG (N = 7). ND = not determined.