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Table 2 Cytokines in salivary gland extract and plasma

From: Local expression of tumor necrosis factor-receptor 1:immunoglobulin G can induce salivary gland dysfunction in a murine model of Sjögren's syndrome

 

Salivary gland extract

(pg/ml per 20 mg wet SG)

Plasma (pg/ml)

 

LacZ

TNFR1:IgG

Pvalue

LacZ

TNFR1:IgG

Pvalue

mTNF-α

73.0 (53.0)

24.6 (2.5)

0.9273

21.2 (5.3)

45.5 (15.3)

0.3152

MCP-1

325.0 (222.7)

254.6 (70.6)

1.0000

182.0 (49.0)

95.1 (10.8)

0.0727

mIL-4

23.0 (12.2)

3.8 (1.0)

0.0727

1.2 (0.05)

16.1 (2.3)

*0.0061

mIL-5

94.5 (41.4)

7.3 (1.9)

*0.0061

2.3 (0.04)

30.7 (8.3)

0.0727

mIL-6

109.9 (61.4)

42.4 (15.2)

0.3152

20.7 (8.8)

37.0 (5.7)

0.1636

mIFN-γ

657.9 (305.5)

614.9 (216.1)

0.5273

192.9 (28.5)

511.7 (75.0)

*0.0061

mIL-10

37.6 (14.8)

7.7 (2.0)

0.0727

3.0 (0.4)

27.5 (3.3)

*0.0061

mTGF-β1

4342 (1742)

3.0E6 (7.8E5)

*0.0061

7.8E5 (8.1E4)

1840 (187.7)

*0.0061

mIL-12p70

130.2 (54.3)

6.3 (2.3)

*0.0061

18.3 (11.0)

65.8 (7.4)

*0.0242

mIL-17

53.2 (24.3)

5.4 (1.6)

*0.0242

6.4 (3.1)

12.1 (1.8)

0.1636

hTNFR1

0.0 (0.0)

114.4 (43.5)

ND

   
  1. Protein expression of immunomodulatory molecules after administration of LacZ and TNFR1:IgG in salivary gland extract and plasma. Data shown are mean values +/- SEM. Significant differences are indicated (*) and were determined by non-parametric Wilcoxon's ranksum test. LacZ (N = 4) and TNFR1:IgG (N = 7). ND = not determined.