Therapeutic efficacy and persistence of liposomal dexamethasone phosphate. (a) Joint swelling was assessed by clinical scoring after a single injection of liposomal dexamethasone phosphate (DXM-P) (0.4 mg/kg, 1.6 mg/kg or 4 mg/kg) or after seven daily injections of free DXM-P (0.4 and 1.6 mg/kg). A single dose of free DXM-P at 1.6 mg/kg is also shown for comparison. Saline injections were used as controls. n = 12 for all groups; means ± standard error of the mean. (b) Urine pyridinoline levels 2 and 7 days after cessation of the treatment. *P ≤ 0.05 Mann-Whitney U test versus saline-treated inflamed animals. n = 6 for all groups; means ± standard error of the mean.