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Table 1 Histological evaluation of arthritis in human tumor necrosis factor (TNF)-alpha transgenic mice immunized with TNF kinoid

From: Active immunization to tumor necrosis factor-α is effective in treating chronic established inflammatory disease: a long-term study in a transgenic model of arthritis

Group Number of mice Inflammation score Incidence Destruction score Incidence
TNF-K (3 injections, sacrifice at week 27) 8 0.1 ± 0.1a 2/8b 0.0 ± 0.0a 1/8c
TNF-K (3 injections without maintenance dose, sacrifice at week 45) 8 0.6 ± 0.2d 6/8 0.2 ± 0.1d 3/8
TNF-K (3 injections with maintenance dose, sacrifice at week 45) 7 0.5 ± 0.1d 7/7 0.3 ± 0.1d 5/7
Intermittent infliximab (sacrifice at week 45) 8 1.4 ± 0.1 8/8 0.9 ± 0.2 7/8
Phosphate-buffered saline (sacrifice at week 27) 8 1.6 ± 0.1 8/8 0.9 ± 0.2 7/8
  1. The incidence of inflammation/destruction as evaluated by histology is the number of mice with a score of inflammation/destruction of at least 0.25. Results are given as mean ± standard error of the mean. aP < 0.05 versus phosphate-buffered saline (PBS); bP < 0.01 versus PBS; cP < 0.05 versus PBS; dP < 0.05 versus infliximab. TNF-K, tumor necrosis factor kinoid.