Skip to main content

Table 1 Data distribution and statistical analysis

From: The effect of the pro-inflammatory cytokine tumor necrosis factor-alpha on human joint capsule myofibroblasts

    Fold change of the respective patient sample in the control group (log2)  
Experiment Group Numbera 25th quartile Median 75th quartile P value
MTT assay B: 1 ng/mL TNF-α 36 0.37 0.60 0.85 B vs. A: <0.001
  C: 10 ng/mL TNF-α 68 0.43 0.60 0.85 C vs. A: <0.001
  D: 1 ng/mL TNF-α + 10 μg/mL IFX 36 -0.03 0.13 0.39 D vs. B: <0.001
  E: 10 ng/mL TNF-α + 10 μg/mL IFX 36 0.21 0.38 0.78 E vs. C: <0.001
  F: 10 μg/mL IFX 36 -0.21 0.02 0.30 F vs. A: 0.2
  G: 10 ng/mL TNF-α + 10 μg/mL Diclo 28 0.02 0.16 0.30 G vs. C: 0.031
3D collagen gel B: 1 ng/mL TNF-α 40 -0.01 0.23 0.46 B vs. A: <0.001
  C: 10 ng/mL TNF-α 52 0.71 0.90 1.47 C vs. A: <0.001
  D: 1 ng/mL TNF-α + 10 μg/mL IFX 40 -0.44 -0.22 0.04 D vs. B: <0.001
  E: 10 ng/mL TNF-α + 10 μg/mL IFX 40 -0.35 -0.14 0.19 E vs. C: <0.001
  F: 10 μg/mL IFX 40 -0.23 -0.01 0.15 F vs. A: 0.6
  G: 10 ng/mL TNF-α + 10 μg/mL Diclo 40 0.04 0.17 0.67 G vs. C: 0.002
qPCR       
α-SMA B: 1 ng/mL TNF-α 8 -1.01 -0.14 1.15 B vs. A: 0.8
  C: 10 ng/mL TNF-α 25 -6.29 -5.64 -3.48 C vs. A: <0.001
  D: 1 ng/mL TNF-α + 10 μg/mL IFX 8 -1.20 -0.004 0.90 D vs. B: 0.4
  E: 10 ng/mL TNF-α + 10 μg/mL IFX 8 -0.63 -0.50 0.10 E vs. C: 0.01
  F: 10 μg/mL IFX 8 -0.45 -0.32 -0.12 F vs. A: 0.5
  G: 10 ng/mL TNF-α + 10 μg/mL Diclo 9 -4.85 -4.32 -3.74 G vs. C: 0.015
Collagen type I B: 1 ng/mL TNF-α 8 -0.36 -0.007 0.59 B vs. A: 1.0
  C: 10 ng/mL TNF-α 17 -4.35 -3.47 -3.00 C vs. A: 0.01
  D: 1 ng/mL TNF-α + 10 μg/mL IFX 8 -0.93 -0.30 0.54 D vs. B: 0.2
  E: 10 ng/mL TNF-α + 10 μg/mL IFX 8 -1.03 -0.20 0.50 E vs. C: 0.01
  F: 10 μg/mL IFX 8 -1.60 -0.009 0.27 F vs. A: 0.6
  G: 10 ng/mL TNF-α + 10 μg/mL Diclo 9 -2.21 -1.84 -0.93 G vs. C: 0.015
  1. aNumber of measurements. 3D, three-dimensional; α-SMA, alpha-smooth muscle actin; Diclo, Diclofenac; IFX, infliximab; MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide; qPCR, quantitative polymerase chain reaction; TNF-α, tumor necrosis factor-alpha.