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Table 2 Comparison of the sensitivity of various ACPA and RF tests at stratified specificity

From: The use of citrullinated peptides and proteins for the diagnosis of rheumatoid arthritis

   

Sensitivity at stratified specificity (%)

Reference

Number of patients (RA/control)

Stratified specificity (%)

CCP2

CCP3

MCVa

Other

RF

Bizzaro and colleagues [23]

100/202

98.5

64 to 74b, c, d, e, f

67g, h

62

41 to 47i, j, k

17

Coenen and colleagues [44];

Bossuyt, personal communication

102/196

95.0

76.2 to 77.0b, d, e

75.5g

65.7

69.3j

ND

Damjanovska and colleagues [50];

Thabet, personal communication

566/351

93.4

56.9e

56.2h

52.5

ND

ND

Dejaco and colleagues [51]

164/303

98.7

70.1d

ND

53.7

ND

ND

Innala and colleagues [41]

210/102

98.0

80.4c

78.5 to 79.0g, h

69.0

ND

ND

Mutlu and colleagues [37]

93/83

98.8

57.0 to 60.2l, f

60.2g

29

ND

48.4

Soos and colleagues [52]

119/118

95

74.8

ND

69.7

ND

33.6

Vander Cruyssen and colleagues [53]

272/463

98.5

67.4 to 68.0e

ND

ND

ND

16.3 to 24.4

Vander Cruyssen and colleagues [42] (early arthritis)

92/463

98.7

61.6 to 67.4d, e

58.1g

ND

ND

ND

Vander Cruyssen and colleagues [42] (established RA)

180/463

98.7

65.2 to 77.4d, e

67.1g

ND

ND

ND

Average

 

97.3

69.2

66.1

57.4

 

29.9

  1. Control groups are not identical. ACPA, anti-citrullinated protein antibodies; ND, not determined; RA, rheumatoid arthritis; RF, rheumatoid factor. aAnti-MCV (Orgentec, Mainz, Germany). bCCP IgG (Euroimmun, Lubeck, Germany). cDiastat anti-CCP (Axis-Shield, Dundee, UK). dEliA CCP (Phadia, Freiburg, Germany). eImmunoscan-RA Mark 2 (Euro-Diagnostica, Arnhem, the Netherlands). fQuanta Lite CCP IgG (Inova, San Diego, CA, USA). gQuanta Lite CCP 3.0 IgG (Inova). hQuanta Lite CCP 3.1 IgG-IgA (Inova). iCPA (Genesis, Littleport, UK). jAeskulisa RA CP-Detect (Aesku, Wendelsheim, Germany). kVCP IgG (Astra, Hamburg, Germany). lAxSYM anti-CCP (Abbott, Princeton, NJ, USA).