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Table 2 Comparison of the sensitivity of various ACPA and RF tests at stratified specificity

From: The use of citrullinated peptides and proteins for the diagnosis of rheumatoid arthritis

    Sensitivity at stratified specificity (%)
Reference Number of patients (RA/control) Stratified specificity (%) CCP2 CCP3 MCVa Other RF
Bizzaro and colleagues [23] 100/202 98.5 64 to 74b, c, d, e, f 67g, h 62 41 to 47i, j, k 17
Coenen and colleagues [44];
Bossuyt, personal communication
102/196 95.0 76.2 to 77.0b, d, e 75.5g 65.7 69.3j ND
Damjanovska and colleagues [50];
Thabet, personal communication
566/351 93.4 56.9e 56.2h 52.5 ND ND
Dejaco and colleagues [51] 164/303 98.7 70.1d ND 53.7 ND ND
Innala and colleagues [41] 210/102 98.0 80.4c 78.5 to 79.0g, h 69.0 ND ND
Mutlu and colleagues [37] 93/83 98.8 57.0 to 60.2l, f 60.2g 29 ND 48.4
Soos and colleagues [52] 119/118 95 74.8 ND 69.7 ND 33.6
Vander Cruyssen and colleagues [53] 272/463 98.5 67.4 to 68.0e ND ND ND 16.3 to 24.4
Vander Cruyssen and colleagues [42] (early arthritis) 92/463 98.7 61.6 to 67.4d, e 58.1g ND ND ND
Vander Cruyssen and colleagues [42] (established RA) 180/463 98.7 65.2 to 77.4d, e 67.1g ND ND ND
Average   97.3 69.2 66.1 57.4   29.9
  1. Control groups are not identical. ACPA, anti-citrullinated protein antibodies; ND, not determined; RA, rheumatoid arthritis; RF, rheumatoid factor. aAnti-MCV (Orgentec, Mainz, Germany). bCCP IgG (Euroimmun, Lubeck, Germany). cDiastat anti-CCP (Axis-Shield, Dundee, UK). dEliA CCP (Phadia, Freiburg, Germany). eImmunoscan-RA Mark 2 (Euro-Diagnostica, Arnhem, the Netherlands). fQuanta Lite CCP IgG (Inova, San Diego, CA, USA). gQuanta Lite CCP 3.0 IgG (Inova). hQuanta Lite CCP 3.1 IgG-IgA (Inova). iCPA (Genesis, Littleport, UK). jAeskulisa RA CP-Detect (Aesku, Wendelsheim, Germany). kVCP IgG (Astra, Hamburg, Germany). lAxSYM anti-CCP (Abbott, Princeton, NJ, USA).