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Table 3 Comparison of ACPA and RF tests in terms of positive and negative predictive values

From: The use of citrullinated peptides and proteins for the diagnosis of rheumatoid arthritis

   CCP2 CCP3 MCV RF
Reference Number of patients (RA/control) PPV (%) NPV (%) PPV (%) NPV (%) PPV (%) NPV (%) PPV (%) NPV (%)
Luis Caro-Oleas and colleagues [54] 124/158 95.2 73.1 92.3 70.5    90.9 73.6
Coenen and colleagues [44]d 133/165 89.7 to 91.4a 87.1 to 89.1a 76.7 88.2 80.0 87.2   
Correia and colleagues [39] 86/90 92.6 to 96.7b 72.9 to 78.7b 91.9 to 94.9b 74.4 to 74.6b    80.3 72.4
Dos Anjos and colleagues [40] 70/88 91.7 84.7 90.6 87.2     
Liu and colleagues [33] 170/136 95.5 66.8    93.7 77.4 82.0 69.9
Lutteri and colleagues [24] 120/170 87.7 to 96.2c 76.6 to 78.3c 92.6 78.1    77.9 79.5
Sghiri and colleagues [29] 170/309 91.1 86.3    66.0 84.7 58.6 79.9
Soos and colleagues [52] 119/118 97.6 74.4    90.0 78.8 80.2 74.0
Ursum and colleagues [48] 123/39 95.8     96.1    
Van der Linden and colleagues [17] 201/424 67.1 79.0 64.0 80.0 56.3 79.2 61.7 77.8
Average   91.2 78.4 84.9 79.8 80.4 81.5 75.9 75.3
  1. Control groups are not identical. ACPA, anti-citrullinated protein antibodies; MCV, mutated citrullinated vimentin; NPV, negative predictive value; PPV, positive predictive value; RA, rheumatoid arthritis; RF, rheumatoid factor. aThree CCP2 tests used. bTwo CCP2 tests and two cut-off values used. cSix CCP2 tests used. dCoenen and collaborators also used the citrullinated filaggrin test (CPA; Genesis, Littleport, UK): PPV, 85.5; NPV, 85.6.