The use of citrullinated peptides and proteins for the diagnosis of rheumatoid arthritis

Table 3 Comparison of ACPA and RF tests in terms of positive and negative predictive values

		CCP2		CCP3		MCV		RF
Reference	Number of patients (RA/control)	PPV (%)	NPV (%)	PPV (%)	NPV (%)	PPV (%)	NPV (%)	PPV (%)	NPV (%)
Luis Caro-Oleas and colleagues [54]	124/158	95.2	73.1	92.3	70.5			90.9	73.6
Coenen and colleagues [44]^d	133/165	89.7 to 91.4^a	87.1 to 89.1^a	76.7	88.2	80.0	87.2
Correia and colleagues [39]	86/90	92.6 to 96.7^b	72.9 to 78.7^b	91.9 to 94.9^b	74.4 to 74.6^b			80.3	72.4
Dos Anjos and colleagues [40]	70/88	91.7	84.7	90.6	87.2
Liu and colleagues [33]	170/136	95.5	66.8			93.7	77.4	82.0	69.9
Lutteri and colleagues [24]	120/170	87.7 to 96.2^c	76.6 to 78.3^c	92.6	78.1			77.9	79.5
Sghiri and colleagues [29]	170/309	91.1	86.3			66.0	84.7	58.6	79.9
Soos and colleagues [52]	119/118	97.6	74.4			90.0	78.8	80.2	74.0
Ursum and colleagues [48]	123/39	95.8				96.1
Van der Linden and colleagues [17]	201/424	67.1	79.0	64.0	80.0	56.3	79.2	61.7	77.8
Average		91.2	78.4	84.9	79.8	80.4	81.5	75.9	75.3

Control groups are not identical. ACPA, anti-citrullinated protein antibodies; MCV, mutated citrullinated vimentin; NPV, negative predictive value; PPV, positive predictive value; RA, rheumatoid arthritis; RF, rheumatoid factor. ^aThree CCP2 tests used. ^bTwo CCP2 tests and two cut-off values used. ^cSix CCP2 tests used. ^dCoenen and collaborators also used the citrullinated filaggrin test (CPA; Genesis, Littleport, UK): PPV, 85.5; NPV, 85.6.

ISSN: 1478-6362