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Table 1 Baseline characteristics of patients

From: Risk of incident or recurrent malignancies among patients with rheumatoid arthritis exposed to biologic therapy in the German biologics register RABBIT

  Patients with prior malignancy   Patients without prior malignancy   
  Biologic Control Total P# Biologic Control Total P# P##
n 67 55 122   3279 1719 4998   
Female n (%) 45 (67.2) 41 (74.5) 86 (70.5) 0.43 2564 (78.2) 1353 (78.7) 3917 (78.4) 0.671 0.047
Age (mean, SD) 64.0 (9.0) 63.2 (7.7) 63.7 (8.4) 0.62 53.6 (12.3) 55.9 (11.5) 54.4 (12.1) < 0.0001 < 0.001
Disease duration (yrs), median (IQR) 10 (6, 16.5) 7 (3, 13) 9 (4, 16) 0.02 9 (5, 17) 6 (2.5, 12) 8 (4, 15) < 0.0001 0.286
Time from prior cancer to study entry (yrs), median (IQR) 5 (2, 9) 5 (3, 11) 5 (2, 10) 0.77      
Follow-up time (yrs), median (IQR) 2.1 (1.4, 3.0) 2.5 (1.0, 4.0) 2.1 (1.1, 3.1) 0.43 2.4 (1.4, 3.1) 2.5 (1.3, 3.3) 2.4 (1.3, 3.1) 0.081 0.611
Rheumatoid factor positive n (%) 53 (79.1) 46 (83.6) 99 (81.1) 0.64 2629 (80.2) 1225 (71.3) 3854 (77.1) < 0.0001 0.327
DAS28 (mean, SD) 5.7 (1.3) 5.4 (1.1) 5.6 (1.2) 0.04 5.8 (1.3) 5.0 (1.3) 5.5 (1.3) < 0.0001 0.282
ESR (mm/h), median (IQR) 38 (18, 51) 26 (15, 42) 32 (17, 50) 0.12 30 (16, 48) 22 (12, 38) 27 (14, 44) < 0.0001 0.080
CRP (mg/L), median (IQR) 25 (10, 46) 15 (8, 30) 19 (9, 43) 0.07 17 (8, 38) 12 (5, 27) 15 (7, 34) < 0.0001 0.146
FFbH (mean, SD) 52.1 (21.3) 59.9 (23.5) 55.7 (22.5) 0.02 57.0 (23.0) 66.8 (21.4) 60.4 (22.9) < 0.0001 0.025
Smoking ever n (%) 23 (57.5) 15 (55.6) 38 (56.7) 1.00 878 (46.9) 473 (46.4) 1351 (46.7) 0.328 0.13
No. of previous DMARDs (mean, SD) 3.7 (1.5) 1.9 (1.0) 2.9 (1.6) < 0.001 3.6 (1.4) 1.9 (1.1) 2.9 (1.5) < 0.0001 0.656
COPD n (%) 3 (4.4) 6 (10.9) 9 (7.3) 0.30 163 (5) 81 (4.7) 244 (4.9) 0.685 0.205
Chronic renal disease n (%) 4 (5.9) 1 (1.8) 5 (4.1) 0.38 134 (4.1) 29 (1.7) 163 (3.3) < 0.0001 0.603
Chronic lung disease n (%) 5 (7.4) 1 (1.8) 6 (4.9) 0.22 93 (2.8) 29 (1.7) 122 (2.4) 0.012 0.129
Chronic gastrointest. disease n (%) 12 (17.6) 5 (9.1) 17 (13.9) 0.2 281 (8.6) 138 (8.0) 419 (8.4) 0.510 0.047
  1. Values are means and standard deviations if not otherwise specified. IQR = inter quartile range; FFbH = Hannover Functional Status Questionnaire measuring functional capacity in percent of full function; DAS28: disease activity score based on 28 joint counts;
  2. # = P-value for comparison between biologic and control group within strata according to prior malignancy status, ## = comparison between strata