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Table 4 Hazard ratios of developing a malignancy

From: Risk of incident or recurrent malignancies among patients with rheumatoid arthritis exposed to biologic therapy in the German biologics register RABBIT

  Univariate Cox regression Multivariate analysis
  HR 95% CI P adjusted HR 95% CI P
Characteristics at baseline       
Age (per 10 yrs increase) 1.82 1.44 to 2.31 < 0.0001 1.71 1.35 to 2.17 < 0.0001
Male vs. female 1.61 0.98 to 2.65 0.062 1.47 0.89 to 2.43 0.13
Co-morbid conditions:       
   COPD 3.64 1.92 to 6.91 < 0.0001 2.63 1.37 to 5.04 0.004
   Gastrointestinal disease 2.19 1.20 to 3.98 0.010 1.81 0.99 to 3.30 0.0534
   Renal disease 1.93 0.70 to 5.28 0.20    
Characteristics at follow-up       
DAS28 (per unit increase) 1.24 1.02 to 1.50 0.034    
DAS28       
   < 3.2 Referent      
   3.2 to 5.1 1.28 0.54 to 3.06 0.58    
   > 5.1 2.00 0.82 to 4.86 0.13    
Ever exposed to       
   Conventional DMARDs only Referent    Referent   
   Anti-TNF agents 0.61 0.39 to 0.97 0.039 0.70 0.44 to 1.12 0.133
   Anakinra 1.16 0.47 to 2.89 0.75 1.39 0.56 to 3.48 0.480