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Table 5 Patient characteristics of cases and matched controls

From: Risk of incident or recurrent malignancies among patients with rheumatoid arthritis exposed to biologic therapy in the German biologics register RABBIT

  Cases (with incident malignancy) Matched controls P
N 74 74  
Characteristics at study entry    
Females# n (%) 52 (70.3) 52 (70.3) n.a.
Age# (mean, SD) 61.3 (8.9) 61.4 (8.5) 0.97
Observation time# (years) (median, IQR) 2.9 (1.8, 4.0) 2.9 (1.6, 3.9) 0.25
DAS28# (mean, SD) 5.6 (1.0) 5.7 (1.0) 0.31
Smoking status#    
Nonsmoker 16 (21.6) 16 (21.6) n.a.
Smoker n (%) 19 (25.7) 19 (25.7)  
Unknown status n (%) 39 (52.7) 39 (52.7)  
Disease duration (years) (median, IQR) 7 (3,14) 9 (5,16) 0.22
Functional status, FFbH (mean, SD) 57.1 (22.3) 63.2 (22.6) 0.058
Characteristics at follow-up    
DAS28 (mean, SD)$ 5.0 (1.2) 4.9 (1.2) 0.41
   Ever exposed to biologics n (%) 44 (59.5) 45 (60.8) 1.0
   Ever exposed to anti-TNFα agents & 44 (59.5) 44 (59.5) 1.0
   Ever exposed to anakinra& 5 (6.8) 5 (6.8) 1.0
Among them    
Cases with solid tumors (n = 68)    
   Ever exposed to biologics 39 (57.4) 43 (63.2) 0.56
   Ever exposed to anti-TNFα agents 39 (57.4) 42 (61.8) 0.70
   Ever exposed to anakinra 5 (7.4) 5 (7.4) 1.0
Cases with non-Hodgkin's Lymphoma (n = 6)    
Characteristics at study entry    
Females # n(%) 5 (83.3) 5 (83.3) n.a.
Age # (mean, SD) 65.2 (6.5) 66.8 (8.0) 0.13
Disease duration 5.5 (4,13) 7 (5,11) 0.53
Functional status, FFbH (mean, SD) 52.8 (31.4) 54.2 (27.5) 0.90
DAS28 # (mean, SD) 5.9 (0.6) 6.2 (0.5) 0.29
Characteristics at follow-up    
DAS28 (mean, SD) $ 5.2 (0.7) 5.5 (0.7) 0.14
Ever exposed to anti-TNFα agents 5 (83.3) 2 (33.3) 0.38
  1. # matching criteria (further matching criteria not shown in the table = COPD, other chronic lung disease, chronic renal disease, chronic gastrointestinal disease, chronic liver disease, and psoriasis)
  2. &five cases and four controls received anti-TNFα agents and anakinra (at different points in time)
  3. $cases = mean of DAS28 values over time points until six months prior to the cancer diagnosis, matched controls: mean of DAS28 values over time points of the corresponding case