Development of bone marrow lesions is associated with adverse effects on knee cartilage while resolution is associated with improvement - a potential target for prevention of knee osteoarthritis: a longitudinal study

Table 2 Relation between compartment specific incident bone marrow lesions and longitudinal change in knee cartilage (n = 234)

	Univariate analysis regression coefficient/odds ratio(95% CI)	Pvalue	Multivariate analysis regression coefficient/odds ratio (95% CI)*	Pvalue
Medial compartment
Annual change in cartilage volume	4.12 (-19.30, 27.60)	0.73	2.37 (-21.78, 26.53)¹	0.85
Cartilage defects progress vs no change	1.86 (0.70, 4.93)	0.21	2.63 (0.93, 7.44)²	0.07
Lateral compartment
Annual change in cartilage volume	21.2 (-5.86, 48.20)	0.12	18.04 (-9.72, 45.80)¹	0.2
Cartilage defects progress vs no change	3.0 (1.01, 8.93)	0.05	3.13 (1.01, 9.68)²	0.05

¹ Annual change in tibial cartilage volume if an incident bone marrow lesion (BML) developed compared with if no BML developed after adjusting for age, gender, body mass index (BMI) and respective baseline tibial plateau area
² Odds ratio for cartilage defects to progress if an incident BML developed compared with if no BML developed after adjusting for age, gender, BMI and respective baseline cartilage volume
CI = confidence interval.

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