Development of bone marrow lesions is associated with adverse effects on knee cartilage while resolution is associated with improvement - a potential target for prevention of knee osteoarthritis: a longitudinal study

Table 3 Relation between compartment specific resolution compared with persistence of bone marrow lesions and change in knee cartilage (n = 37)

	Univariate analysis regression coefficient/odds ratio (95% CI)	Pvalue	Multivariate analysis regression coefficient/odds ratio (95% CI)*	Pvalue
Medial compartment
Annual change in cartilage volume	-28.70 (-58.11, 0.68)	0.05	-35.90 (-65.00, -6.82)¹	0.02
Cartilage defects progress vs no change	0.23 (0.05, 1.08)	0.06	0.20 (0.04, 1.09)²	0.06
Lateral compartment
Annual change in cartilage volume	24.70 (-18.88, 68.37)	0.26	23.41 (-23.13, 70)¹	0.31
Cartilage defects progress vs no change	1.08 (0.24, 4.90)	0.92	1.08 (0.22, 5.39)²	0.92

¹ Annual change in tibial cartilage volume if a bone marrow lesion (BML) resolved vs persisted after adjusting for age, gender, body mass index (BMI) and respective baseline tibial plateau area
² Odds ratio for cartilage defects to progress if a BML resolved vs persisted after adjusting for age, gender, BMI and baseline cartilage volume
CI = confidence interval.

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