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Table 3 Relation between compartment specific resolution compared with persistence of bone marrow lesions and change in knee cartilage (n = 37)

From: Development of bone marrow lesions is associated with adverse effects on knee cartilage while resolution is associated with improvement - a potential target for prevention of knee osteoarthritis: a longitudinal study

  Univariate analysis regression coefficient/odds ratio (95% CI) Pvalue Multivariate analysis regression coefficient/odds ratio
(95% CI)*
Pvalue
Medial compartment     
Annual change in cartilage volume -28.70 (-58.11, 0.68) 0.05 -35.90 (-65.00, -6.82)1 0.02
Cartilage defects progress vs no change 0.23 (0.05, 1.08) 0.06 0.20 (0.04, 1.09)2 0.06
Lateral compartment     
Annual change in cartilage volume 24.70 (-18.88, 68.37) 0.26 23.41 (-23.13, 70)1 0.31
Cartilage defects progress vs no change 1.08 (0.24, 4.90) 0.92 1.08 (0.22, 5.39)2 0.92
  1. 1 Annual change in tibial cartilage volume if a bone marrow lesion (BML) resolved vs persisted after adjusting for age, gender, body mass index (BMI) and respective baseline tibial plateau area
  2. 2 Odds ratio for cartilage defects to progress if a BML resolved vs persisted after adjusting for age, gender, BMI and baseline cartilage volume
  3. CI = confidence interval.