Figure 1From: Regulation of IFN response gene activity during infliximab treatment in rheumatoid arthritis is associated with clinical response to treatmentDifferential regulation of interferon (IFN) response genes upon tumor necrosis factor (TNF) blockade. The expression levels of 34 type I IFN response genes were determined by cDNA microarray analysis in peripheral blood cells of 15 patients before (T0) and 1 month after (T1) anti-TNF treatment. (a) Subsequently, for each patient, the expression levels were averaged (note: data are in log2 space) and baseline levels were compared with post-treatment levels. The patients whose IFN response gene levels are induced after TNF blockade are indicated by red lines, and patients with a downregulation are indicated by green lines. Subsequently, the expression levels of three IFN response genes (RSAD2, IFI44L, and OAS1) were measured by quantitative real-time polymerase chain reaction (PCR) in an independent group of 18 patients. (b) The expression levels of the three genes were averaged, and baseline levels were compared with post-treatment levels. ns, not significant using a paired t test analysis.Back to article page