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Figure 1 | Arthritis Research & Therapy

Figure 1

From: Regulation of IFN response gene activity during infliximab treatment in rheumatoid arthritis is associated with clinical response to treatment

Figure 1

Differential regulation of interferon (IFN) response genes upon tumor necrosis factor (TNF) blockade. The expression levels of 34 type I IFN response genes were determined by cDNA microarray analysis in peripheral blood cells of 15 patients before (T0) and 1 month after (T1) anti-TNF treatment. (a) Subsequently, for each patient, the expression levels were averaged (note: data are in log2 space) and baseline levels were compared with post-treatment levels. The patients whose IFN response gene levels are induced after TNF blockade are indicated by red lines, and patients with a downregulation are indicated by green lines. Subsequently, the expression levels of three IFN response genes (RSAD2, IFI44L, and OAS1) were measured by quantitative real-time polymerase chain reaction (PCR) in an independent group of 18 patients. (b) The expression levels of the three genes were averaged, and baseline levels were compared with post-treatment levels. ns, not significant using a paired t test analysis.

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