TY - JOUR AU - Zheng, Xiufen AU - Suzuki, Motohiko AU - Zhang, Xusheng AU - Ichim, Thomas E. AU - Zhu, Fei AU - Ling, Hong AU - Shunnar, Aminah AU - Wang, Michael H. AU - Garcia, Bertha AU - Inman, Robert D. AU - Min, Wei-Ping PY - 2010 DA - 2010/01/26 TI - RNAi-mediated CD40-CD154 interruption promotes tolerance in autoimmune arthritis JO - Arthritis Research & Therapy SP - R13 VL - 12 IS - 1 AB - We have previously demonstrated that ex vivo inhibition of costimulatory molecules on antigen-pulsed dendritic cells (DCs) can be useful for induction of antigen-specific immune deviation and suppression of autoimmune arthritis in the collagen induced arthritis (CIA) model. The current study evaluated a practical method of immune modulation through temporary systemic inhibition of the costimulatory molecule CD40. SN - 1478-6354 UR - https://doi.org/10.1186/ar2914 DO - 10.1186/ar2914 ID - Zheng2010 ER -