Figure 7
From: CD16 (FcRγIII) as a potential marker of osteoclast precursors in psoriatic arthritis
Elevated CD16 surface expression was associated with increased bone erosion activity in PsA monocytes. Sterile sorted MHCII+CD16+ and MHCII+CD16int cells were co-cultured with bone slices in the presence of receptor activator of nuclear factor kappa-B ligand (RANKL) and macrophage colony-stimulating factor (M-CSF) for 14 days. (a and b) Osteoclast (OC) were identified by tartrate-resistant acid phosphatase (TRAP) staining, and (c and d) bone erosion pits were visualized after toluidine blue staining.