TY - JOUR AU - Scotto d'Abusco, Anna AU - Politi, Laura AU - Giordano, Cesare AU - Scandurra, Roberto PY - 2010 DA - 2010/01/29 TI - A peptidyl-glucosamine derivative affects IKKα kinase activity in human chondrocytes JO - Arthritis Research & Therapy SP - R18 VL - 12 IS - 1 AB - Nuclear factor-κB (NF-κB) transcription factor regulates several cell signaling pathways, such as differentiation and inflammation, which are both altered in osteoarthritis. Inhibitor κB kinase (IKK)α and IKKβ are kinases involved in the activation of the NF-κB transcription factor. The aim of the present study was to determine the effects of glucosamine (GlcN), which is administered in the treatment of osteoarthritis, and of its 2-(N-Acetyl)-L-phenylalanylamido-2-deoxy-β-D-glucose (NAPA) derivative on IKK kinases and, consequently, on NF-κB activation in human chondrocytes. SN - 1478-6354 UR - https://doi.org/10.1186/ar2920 DO - 10.1186/ar2920 ID - Scotto d'Abusco2010 ER -