Transcriptional profiling of bovine intervertebral disc cells: implications for identification of normal and degenerate human intervertebral disc cell phenotypes

Table 4 Previously identified marker

Gene description	Gene symbol	AC mean	AF mean	NP mean	Fold change (NP/AC)	Fold change (NP/AF)	Fold change (NP/AC&AF)
matrix metallopeptidase 2	MMP2	200.20	155.41	121.53	-1.65	-1.28	-1.56
solute carrier family 2, member 1	SLC2A1	1200.57	1211.32	1281.16	1.07	1.06	1.04
hypoxia-inducible factor 1, alpha	HIF1A	3985.62	7783.65	2552.07	-1.56	-3.05	-2.50
vascular endothelial growth factor	VEGF	1874.33	5661.88	2233.09	1.19	-2.54	-1.86
CD24 molecule	CD24	521.84	44.59	86.75	-6.02	1.95	-3.42
keratin 19	KRT19	0.91	0.65	32.59	35.81	50.47	19.88
glypican 3	GPC3	4.24	37.63	13.28	3.13	-2.83	-1.78
annexin A3	ANXA3	7.64	63.66	8.26	1.08	-7.71	-7.44
pleiotrophin	PTN	208.08	54.11	1.10	-189.18	-49.19	-152.58
vimentin	VIM	4625.18	4749.33	3508.86	-1.32	-1.35	-1.35
cartilage oligomeric matrix protein	COMP	6053.50	2986.89	2786.96	-2.17	-1.07	-1.78
matrix Gla protein	MGP	8480.52	7742.10	2865.30	-2.96	-2.70	-3.21
alpha-2-macroglobulin	A2M	9.49	26.62	11.37	1.20	-2.34	-1.77
annexin A4	ANXA4	1223.21	2318.40	1273.29	1.04	-1.82	-1.55
desmocollin 2	DSC2	1.88	140.72	68.18	36.30	-2.06	-1.22
keratin 18	KRT18	0.01	0.04	94.10	15990.45	2647.60	1860.77
neural cell adhesion molecule 1	NCAM1	0.76	0.94	12.64	16.55	13.43	10.06

Bovine microarray data for previously identified markers. Mean fluorescence intensity expression is shown for each cell type (AC, AF and NP) along with the calculated fold change values. AC, articular cartilage; AF, annulus fibrosus; NP, nucleus pulposus.