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Table 2 Joint inflammation and bone destruction

From: Functional consequences of DECTIN-1early stop codon polymorphism Y238X in rheumatoid arthritis

Variable n Homozygous wild-type for DECTIN-1 n Heterozygous for
DECTIN-1Y238X
Pvalue
Age (years) 221 53 (14) 41 53 (13) 0.87
Female 221 147 (66%) 41 25 (61%) 0.49
Rheumatoid factor + 220 163 (74%) 41 34 (83%) 0.23
DAS28 baseline 212 5.2 (1.5) 40 5.3 (1.4) 0.55
Average DAS28 year 0-3 214 3.9 (1.1) 41 4.1 (1.2) 0.37
Average DAS28 year 4-6 203 3.5 (1.1) 35 3.9 (1.3) 0.05
Average DAS28 year 7-9 166 3.5 (1.2) 28 4.0 (1.3) 0.07
Joint-damage score baseline 221 0 (0-2) 41 0 (0-3) 0.87
Joint-damage score year 3 221 6 (1-15) 41 5 (0-18) 0.70
Joint-damage score year 6 154 13 (2-26) 29 14 (3-26) 0.98
Joint-damage score year 9 109 20 (8-35) 24 20 (3-37) 0.98
  1. DAS28: Disease Activity Score using 28 joint counts. Baseline and follow-up values of disease markers of joint inflammation and bone destruction of 262 RA patients, stratified by DECTIN-1 genotype. Values are numbers (percentage), medians (p25-p75) or means (SD), as indicated by the notation.