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Table 3 Between-group differences for DECTIN-1 Y238X genotype in joint-damage progression

From: Functional consequences of DECTIN-1early stop codon polymorphism Y238X in rheumatoid arthritis

Parameter Estimate SE Pvalue
Intercept 3.32 0.32 < 0.0001
DECTIN-1 genotype 0.05 0.79 0.95
Intercept 1.07 0.58 0.065
DECTIN-1 genotype -0.40 0.71 0.57
Joint damage at baseline 2.65 0.53 < 0.0001
Rheumatoid factor + 1.28 0.63 0.043
Average DAS28a 1.26 0.24 < 0.0001
  1. DAS28: Disease Activity Score using 28 joint counts. Results of the linear regression model with 262 RA patients. The upper model tests the difference in annual joint-damage progression rate between wild-type patients and patients heterozygous for the DECTIN-1 Y238X polymorphism, indicated by the estimate of DECTIN-1 genotype (P = 0.95). The lower model tests the same (P = 0.57), with addition of baseline joint damage, rheumatoid factor positivity, and the time-averaged DAS28 as confounders. aTime-averaged DAS28 was centered.