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Table 2 Absolute number of stem cells and circulating endothelial progenitor cells in peripheral blood (cells per 106 lineage-negative mononuclear cells)

From: Enhanced late-outgrowth circulating endothelial progenitor cell levels in rheumatoid arthritis and correlation with disease activity

Cells per 106 Lin- mononuclear cells

RA patients (n = 59)

Controls (n = 36)

Pvalue

Lin-/7AAD-/CD34+/CD133+

  

0.0002

   Median (range)

2,484 (213-26,613)

1,068 (123-2,270)

 

   25%-75% percentile

1,141-5,943

610.5-1,575

 

Lin-/7AAD-/CD34+/VEGFR-2+

  

0.0026

   Median (range)

259 (27-588)

103 (11-1,105)

 

   25%-75% percentile

124-493

49.75-193.8

 

Lin-/7AAD-/CD133+/VEGFR-2+

  

0.0276

   Median (range)

151 (45-964)

125 (25-555)

 

   25%-75% percentile

93-387

99.25-192.8

 

Lin-/7AAD-/CD34+/CD133+/VEGFR-2+ (EPCs)

  

0.0007

   Median (range)

112 (27-588)

60 (5-275)

 

   25%-75% percentile

53-227

26-109.8

 

Lin-/7AAD-/CD105+/CD133-/VEGFR-2+(CECs)

  

0.1727

   Median (range)

173 (12-989)

139 (30-426)a

 

   25%-75% percentile

57-341

73-189

 

Ratio EPCs/CECs, median (range)

1 (0.07-4.28)

1 (0.2-2.02)a

0.3946

  1. aCirculating endothelial cell (CEC) number has been evaluated in 15 healthy controls. 7AAD, 7-aminoactinomycin D; DAS-28, 28-joint disease activity score; EPC, endothelial progenitor cell; Lin-, lineage-negative; RA, rheumatoid arthritis; VEGFR-2, vascular endothelial growth factor receptor-2.