Table 2 Concentration effects of pentosan polysulfate on hyaluronan deposition in human mesenchymal progenitor cell micromass cultures

Control 0.0

1.54 ± 0.03

1.58 ± 0.01

1.55 ± 0.06

2.10 ± 0.03^§

0.1

1.34 ± 0.05^#

1.76 ± 0.26

1.30 ± 0.08^#

1.64 ± 0.07^#

0.5

1.34 ± 0.11^#

1.74 ± 0.07

1.22 ± 0.17^#

1.89 ± 0.01^#

1.0

1.09 ± 0.05^#

1.98 ± 0.29

1.23 ± 0.06^#

2.42 ± 0.32

2.5

1.50 ± 0.17

1.78 ± 0.23

1.32 ± 0.12^#

2.24 ± 0.39

5.0

1.28 ± 0.05^#

2.16 ± 0.20*

1.33 ± 0.07^#

2.27 ± 0.24

10.0

1.25 ± 0.03^#

2.39 ± 0.32

0.84 ± 0.09^#

2.57 ± 0.31

20.0

1.36 ± 0.05^#

2.31 ± 0.33*

1.32 ± 0.06^#

2.54 ± 0.04**

Statistical significance

^#PPS < control (P < 0.05)

*PPS > control (P < 0.05)

^#PPS < control (P < 0.05)

^§Matrix > media (P < 0.05), ^#PPS < control (P < 0.05), **PPS > control (P < 0.005)