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Table 2 Concentration effects of pentosan polysulfate on hyaluronan deposition in human mesenchymal progenitor cell micromass cultures

From: Pentosan polysulfate promotes proliferation and chondrogenic differentiation of adult human bone marrow-derived mesenchymal precursor cells

PPS concentration (μg/ml) HA concentration (μg/ml)
  Media 7 days Matrix 7 days Media 10 days Matrix 10 days
Control 0.0 1.54 ± 0.03 1.58 ± 0.01 1.55 ± 0.06 2.10 ± 0.03§
0.1 1.34 ± 0.05# 1.76 ± 0.26 1.30 ± 0.08# 1.64 ± 0.07#
0.5 1.34 ± 0.11# 1.74 ± 0.07 1.22 ± 0.17# 1.89 ± 0.01#
1.0 1.09 ± 0.05# 1.98 ± 0.29 1.23 ± 0.06# 2.42 ± 0.32
2.5 1.50 ± 0.17 1.78 ± 0.23 1.32 ± 0.12# 2.24 ± 0.39
5.0 1.28 ± 0.05# 2.16 ± 0.20* 1.33 ± 0.07# 2.27 ± 0.24
10.0 1.25 ± 0.03# 2.39 ± 0.32 0.84 ± 0.09# 2.57 ± 0.31
20.0 1.36 ± 0.05# 2.31 ± 0.33* 1.32 ± 0.06# 2.54 ± 0.04**
Statistical significance #PPS < control (P < 0.05) *PPS > control (P < 0.05) #PPS < control (P < 0.05) §Matrix > media (P < 0.05), #PPS < control (P < 0.05), **PPS > control (P < 0.005)
  1. Concentration effects of pentosan polysulfate (PPS) on hyaluronan (HA) deposition in the media and matrix of 7-day and 10-day micromass cultures of human mesenchymal progenitor cells (MPCs). Data are mean ± standard deviation of triplicate culture values.