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Table 2 Chronologic overview of literature describing the effect of mesenchymal stem cells on collagen-induced arthritis

From: Discrepancy between the in vitro and in vivoeffects of murine mesenchymal stem cells on T-cell proliferation and collagen-induced arthritis

  MSC source MSC administration  
Reference Organisma Strainb Organc Transfectiond Routee Dosef Timeg Resulth
[26] Mouse C3 Cell line n.a. i.v. 1 × 106 0 0
        21 0
       4 × 106 0 0
        21 -
     IL-10 i.v. 1 × 106 0 0
[23] Mouse C57Bl/10 BM n.a. i.p. 5 × 106 0 +
        21 +
[27] Mouse DBA/1 BM n.a. i.v. 1 × 106 21+28+35 0
     IL-10 i.v. 1 × 106 21+28+35 +
[24] Human n.a. Adipose n.a. i.p. 1 × 106 5 a.d.o. +
  Mouse C57Bl/6 Adipose n.a. i.p. 1 × 106 5 a.d.o. +
  Mouse DBA/1 Adipose n.a. i.p. 1 × 106 5 a.d.o. +
[25] Rat n.s. BM n.a. i.v. 2 × 106 1 a.d.o. +
  1. Mesenchymal stem cells (MSCs) in the studies described were isolated from different organismsa, strainsb, and organsc and transfected (interleukin-10 (IL-10)) or not (n.a.) with IL-10 expression vectorsd. MSCs were administered intravenously (i.v.) or intraperitoneally (i.p.)e at specified dosesf and administered at different time points (that is, days after immunizationg). hResults of the studies were summarized as follows: 0, no effect; -, worsening of symptoms; +, beneficial effect on arthritis symptoms. a.d.o., after disease onset; BM, bone marrow; n.a., not applicable; n.s., not specified.