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Table 1 IL-17 inhibits mouse chondrocyte proteoglycan (PG) synthesis

From: IL-17 derived from juxta-articular bone and synovium contributes to joint degradation in rheumatoid arthritis

Culture conditiona  
IGF-1 IL-1 IL-17 Chondrocyte PG synthesis (%)b
+ - - 100 ± 11
+ + - 58 ± 5*
+ - + 66 ± 8*
+ + + 40 ± 5*
  1. a Mouse patellae incubated with insulin-like growth factor (IGF-1) (0.25 μg/ml), and with and without IL-1 (1 ng/ml), IL-17 (10 ng/ml), or IL-1 and IL-17 for 48 h. b Values represent percentages of sulfate incorporation into proteoglycans ± SD of four separate experiments with six mice per group per experiment. *P < 0.01 compared with IGF-1 alone, by Wilcoxon rank sum test.
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Arthritis Research & Therapy

ISSN: 1478-6362

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