Culture conditiona
| |
---|
IGF-1
|
IL-1
|
IL-17
|
Chondrocyte PG synthesis (%)b
|
---|
+
|
-
|
-
|
100 ± 11
|
+
|
+
|
-
|
58 ± 5*
|
+
|
-
|
+
|
66 ± 8*
|
+
|
+
|
+
|
40 ± 5*
|
- a Mouse patellae incubated with insulin-like growth factor (IGF-1) (0.25 μg/ml), and with and without IL-1 (1 ng/ml), IL-17 (10 ng/ml), or IL-1 and IL-17 for 48 h. b Values represent percentages of sulfate incorporation into proteoglycans ± SD of four separate experiments with six mice per group per experiment. *P < 0.01 compared with IGF-1 alone, by Wilcoxon rank sum test.