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Table 1 IL-17 inhibits mouse chondrocyte proteoglycan (PG) synthesis

From: IL-17 derived from juxta-articular bone and synovium contributes to joint degradation in rheumatoid arthritis

Culture conditiona

 

IGF-1

IL-1

IL-17

Chondrocyte PG synthesis (%)b

+

-

-

100 ± 11

+

+

-

58 ± 5*

+

-

+

66 ± 8*

+

+

+

40 ± 5*

  1. a Mouse patellae incubated with insulin-like growth factor (IGF-1) (0.25 μg/ml), and with and without IL-1 (1 ng/ml), IL-17 (10 ng/ml), or IL-1 and IL-17 for 48 h. b Values represent percentages of sulfate incorporation into proteoglycans ± SD of four separate experiments with six mice per group per experiment. *P < 0.01 compared with IGF-1 alone, by Wilcoxon rank sum test.