Changes in HAQ and PCS in patients treated with biologic therapy. Changes in HAQ and PCS in patients who started a biologic therapy at time 0. Horizontal graphs at y-axis represent curves of the distribution of values for HAQ (above) and PCS (below) at time 0. Annual cost is the annual cost calculated for the 10-year duration before and the 10-year duration after the start of biologic therapy. HAQ, Health Assessment Questionnaire; PCS, SF-36 Physical Component Summary; MCS, SF-36 Mental Component Summary.