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Table 3 Distribution of the SP-D Met11Thr genotype and allele frequencies and corresponding SP-D serum levels (median (95% CI))

From: Circulating surfactant protein -D is low and correlates negatively with systemic inflammation in early, untreated rheumatoid arthritis

  N(%) of RA patients SP-D ng/ml*
RA patients
N(%) of controls SP-D ng/ml*
Controls
P -value
**
Odds ratio ***
Genotype:       
Met11/Met11 41 (27.3) 724 (636; 1,123) 152 (35.8) 1,081 (996; 1,252) P = 0.16 1.0 (ref)
Thr11/Thr11 27 (18.0) 750 (603; 834) 77 (18.1) 896 (788; 955)   1.3 (0.73; 2.4)
Met11/Thr11 82 (54.7) 660 (563; 761) 196 (46.1) 925 (845;1,023)   1.6 (0.97; 2.6)
Allele:       
Met11 164 (54.7)   500 (58.8)   P = 0.22 1.0 (ref)
Thr11 136 (45.3)   350 (41.2)    1.2 (0.9;1.6)
  1. * Kruskal-Wallis test: RA patients: P = 0.13 and controls: P = 0.0023
  2. ** Distribution, P-value calculated using Fishers' Exact test
  3. *** Odds ratio (95% CI) calculated using logistic regression with health status as the dependent variable and genotype/allele, gender and age as independent variables.
  4. CI, confidence interval; SP-D, surfactant protein -D; RA, rheumatoid arthritis; Ref, reference