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Table 3 Distribution of the SP-D Met11Thr genotype and allele frequencies and corresponding SP-D serum levels (median (95% CI))

From: Circulating surfactant protein -D is low and correlates negatively with systemic inflammation in early, untreated rheumatoid arthritis

 

N(%) of RA patients

SP-D ng/ml*

RA patients

N(%) of controls

SP-D ng/ml*

Controls

P -value

**

Odds ratio ***

Genotype:

      

Met11/Met11

41 (27.3)

724 (636; 1,123)

152 (35.8)

1,081 (996; 1,252)

P = 0.16

1.0 (ref)

Thr11/Thr11

27 (18.0)

750 (603; 834)

77 (18.1)

896 (788; 955)

 

1.3 (0.73; 2.4)

Met11/Thr11

82 (54.7)

660 (563; 761)

196 (46.1)

925 (845;1,023)

 

1.6 (0.97; 2.6)

Allele:

      

Met11

164 (54.7)

 

500 (58.8)

 

P = 0.22

1.0 (ref)

Thr11

136 (45.3)

 

350 (41.2)

  

1.2 (0.9;1.6)

  1. * Kruskal-Wallis test: RA patients: P = 0.13 and controls: P = 0.0023
  2. ** Distribution, P-value calculated using Fishers' Exact test
  3. *** Odds ratio (95% CI) calculated using logistic regression with health status as the dependent variable and genotype/allele, gender and age as independent variables.
  4. CI, confidence interval; SP-D, surfactant protein -D; RA, rheumatoid arthritis; Ref, reference