Skip to main content

Table 1 Cytokine and chemokines that play a role in gouty inflammation

From: Gout. Mechanisms of inflammation in gout

Cytokine

Actions contributing to gouty inflammation

Produced by

References

IL-1β

Endothelial adhesion

Monocyte, dendritic cells inflammatory macrophage

[11, 12, 20, 25]

 

Endogenous pyrogen

  

TNFα

Cellular activation

Monocyte, macrophage, lining cell

[11, 12]

 

Endothelial adhesion

  
 

Phagocytosis

  

IL-6

?

Monocyte, macrophage

[11, 17]

Granulocyte colony-stimulating factor

Neutrophil survival and proliferation

Endothelium, macrophage

[11, 17]

CXCL1 (KC, Groa)

Neutrophil chemotaxis

Macrophage, neutrophil

[11]

CXCL8 (IL-8)

Neutrophil chemotaxis

Macrophage, endothelium

[36, 37]

CCL2 (monocyte chemoattractant protein-1)

Monocyte and dendritic cell chemotaxis

 

[11]

 

Mast cell degranulation

  

CCL3 (macrophage inflammatory protein-1)

Neutrophil chemotaxis

Monocyte, macrophage

[11]