Figure 1
From: Slit3 inhibits Robo3-induced invasion of synovial fibroblasts in rheumatoid arthritis
Robo and Slit expression in RASF. The amount of Robo1, Robo2, Robo3, Slit1, Slit2 and Slit3 mRNA expression in rheumatoid arthritis synovial fibroblasts (RASF; n = 5) compared with normal SF (n = 2) in early passages (P3 and P4) was quantified by real-time (RT)-PCR (logarithmic scaling). Robo1 and Robo2 are both expressed in normal SF and RASF, whereas Robo3 is much stronger expressed in RASF compared with normal SF. Slit1, Slit2, and Slit3 are all expressed in normal SF and RASF, with significant reduction of Slit3 expression in RASF (* P < 0.05).