| |
Men
|
Women
|
Postmenopausal women
|
|---|
|
Radiographic knee OA
|
n = 1,053
|
n = 1,574
|
n = 1,330
|
|
Unadjusted
|
1.65 [1.25, 2.17]
|
2.30 [1.84, 2.86]
|
2.18 [1.72, 2.76]
|
|
Adjusted age/race
|
1.12 [0.83, 1.53]
|
1.61 [1.26, 2.05]
|
1.55 [1.19, 2.01]
|
|
+ Lifestyle, clinical
|
1.23 [0.89, 1.70]
|
1.39 [1.08, 1.80]
|
1.35 [1.02, 1.78]
|
|
+ Occupation
|
1.21 [0.85, 1.71]
|
1.48 [1.12, 1.96]
|
1.34 [0.99, 1.81]
|
|
+ HRT
|
N/A
|
N/A
|
1.33 [0.98, 1.79]
|
|
Bilateral radiographic knee OA
|
n = 908
|
n = 1,338
|
n = 1,132
|
|
Unadjusted
|
1.81 [1.25, 2.61]
|
2.77 [2.09, 3.67]
|
2.59 [1.92, 3.49]
|
|
Adjusted age/race
|
1.05 [0.69, 1.59]
|
1.72 [1.26, 2.35]
|
1.68 [1.21, 2.34]
|
|
+ Lifestyle/clinical
|
1.17 [0.76, 1.80]
|
1.45 [1.03, 2.04]
|
1.44 [1.01, 2.07]
|
|
+ Occupation
|
1.06 [0.67, 1.68]
|
1.62 [1.12, 2.36]
|
1.55 [1.05, 2.30]
|
|
+ HRT
|
N/A
|
N/A
|
1.53 [1.03, 2.27]
|
|
Symptomatic knee OA
|
n = 1,052
|
n = 1,571
|
n = 1,327
|
|
Unadjusted
|
2.03 [1.43, 2.86]
|
2.69 [2.06, 3.5]
|
2.39 [1.81, 3.16]
|
|
Adjusted age/ethnicity
|
1.55 [1.06, 2.26]
|
1.90 [1.42, 2.54]
|
1.74 [1.28, 2.36]
|
|
+ Lifestyle, clinical
|
1.71 [1.14, 2.56]
|
1.66 [1.21, 2.27]
|
1.51 [1.08, 2.11]
|
|
+ Occupation
|
1.86 [1.20, 2.87]
|
1.64 [1.16, 2.31]
|
1.46 [1.02, 2.10]
|
|
+ HRT
|
N/A
|
N/A
|
1.46 [1.01, 2.09]
|
|
Bilateral symptomatic knee OA
|
n = 943
|
n = 1,403
|
n = 1,172
|
|
Unadjusted
|
1.50 [0.82, 2.76]
|
3.11 [2.08, 4.64]
|
2.86 [1.86, 4.41]
|
|
Adjusted age/ethnicity
|
0.94 [0.48, 1.84]
|
2.07 [1.33, 3.20]
|
1.99 [1.25, 3.19]
|
|
+ Lifestyle, clinical
|
1.07 [0.53, 2.13]
|
1.75 [1.10, 2.81]
|
1.76 [1.07, 2.91]
|
|
+ Occupation
|
0.90 [0.43, 1.88]
|
1.87 [1.13, 3.11]
|
1.87 [1.09, 3.20]
|
|
+ HRT
|
N/A
|
N/A
|
1.84 [1.07, 3.16]
|
- Odds ratios compare low (<12 years) with high (≥ 12 years) educational attainment for having a knee OA outcome. For all models, data are restricted to individuals having a complete set of nonmissing values for their explanatory variables, and covariates are added (+) cumulatively.
- Adjusted age/race, adjusted for age and race.
- +Lifestyle/Clinical, additionally adjusted for alcohol and tobacco use, BMI, and knee injury.
- +Occupation, additionally adjusted for occupational category, physical activity score.
- +HRT, additionally adjusted for use of hormone replacement therapy.
