|
Men
|
Women
|
Postmenopausal women
|
---|
Radiographic knee OA
|
n = 1,053
|
n = 1,574
|
n = 1,330
|
Education (low)
|
1.21 [0.85, 1.71]
|
1.48 [1.12, 1.96]
|
1.33 [0.98, 1.79]
|
Physical activity (high)
|
1.04 [0.76, 1.42]
|
1.03 [0.80, 1.31]
|
0.99 [0.76, 1.30]
|
Occupation, PD
|
1.04 [0.74, 1.47]
|
0.86 [0.65, 1.14]
|
0.99 [0.73, 1.34]
|
Age 55-64
|
2.30 [1.51, 3.51]
|
1.46 [1.06, 2.02]
|
1.46 [1.00, 2.12]
|
Age 65-74
|
4.39 [2.87, 6.72]
|
2.71 [1.92, 3.84]
|
2.48 [1.66, 3.72]
|
Age 75 and over
|
5.48 [3.12, 9.65]
|
7.13 [4.67, 10.9]
|
6.26 [3.87, 10.1]
|
African American
|
1.31 [0.92, 1.85]
|
0.92 [0.71, 1.20]
|
0.79 [0.59, 1.04]
|
Knee injury
|
2.82 [1.97, 4.05]
|
1.69 [1.24, 2.31]
|
1.74 [1.25, 2.42]
|
BMI/5
|
1.35 [1.16, 1.58]
|
1.71 [1.55, 1.89]
|
1.68 [1.51, 1.87]
|
Current smoking
|
0.60 [0.41, 0.89]
|
0.91 [0.63, 1.31]
|
0.87 [0.58, 1.29]
|
Current alcohol
|
1.11 [0.79, 1.57]
|
0.62 [0.41, 0.95]
|
0.66 [0.42, 1.05]
|
Current HRT
|
N/A
|
N/A
|
0.58 [0.41, 0.83]
|
Bilateral radiographic knee OA
|
n = 908
|
n = 1,338
|
n = 1,132
|
Education (low)
|
1.06 [0.67, 1.68]
|
1.62 [1.12, 2.36]
|
1.53 [1.03, 2.27]
|
Physical activity (high)
|
0.86 [0.57, 1.30]
|
1.02 [0.73, 1.41]
|
0.99 [0.70, 1.40]
|
Occupation, PD
|
1.40 [0.87, 2.25]
|
0.75 [0.52, 1.10]
|
0.81 [0.55, 1.21]
|
Age 55-64
|
4.48 [2.35, 8.55]
|
2.04 [1.28, 3.26]
|
1.87 [1.09, 3.22]
|
Age 65-74
|
8.38 [4.38, 16.0]
|
4.60 [2.81, 7.55]
|
3.92 [2.21, 6.94]
|
Age 75 and over
|
10.6 [4.68, 23.9]
|
13.6 [7.64, 24.2]
|
10.7 [5.60, 20.6]
|
African American
|
1.81 [1.16, 2.83]
|
1.08 [0.77, 1.52]
|
0.91 [0.63, 1.30]
|
Knee injury
|
2.42 [1.49, 3.94]
|
1.71 [1.15, 2.55]
|
1.62 [1.06, 2.48]
|
BMI/5
|
1.46 [1.17, 1.82]
|
2.08 [1.82, 2.37]
|
2.03 [1.76, 2.35]
|
Current smoking
|
0.59 [0.35, 0.99]
|
0.79 [0.46, 1.35]
|
0.69 [0.38, 1.24]
|
Current alcohol
|
1.20 [0.76, 1.90]
|
0.76 [0.43, 1.34]
|
0.93 [0.52, 1.68]
|
Current HRT
|
N/A
|
N/A
|
0.44 [0.26, 0.74]
|
Symptomatic knee OA
|
n = 1,052
|
n = 1,571
|
n = 1,327
|
Education (low)
|
1.86 [1.20, 2.87]
|
1.64 [1.16, 2.31]
|
1.46 [1.01, 2.09]
|
Physical activity (high)
|
0.83 [0.57, 1.22]
|
1.23 [0.90, 1.66]
|
1.22 [0.88, 1.68]
|
Occupation, PD
|
0.86 [0.56, 1.33]
|
1.01 [0.72, 1.44]
|
1.06 [0.74, 1.53]
|
Age 55-64
|
2.45 [1.40, 4.27]
|
2.36 [1.53, 3.64]
|
2.14 [1.30, 3.52]
|
Age 65-74
|
4.33 [2.49, 7.55]
|
3.28 [2.05, 5.26]
|
2.95 [1.72, 5.06]
|
Age 75 and over
|
4.83 [2.35, 9.92]
|
12.2 [7.18, 20.8]
|
10.9 [5.94, 19.9]
|
African American
|
1.13 [0.73, 1.75]
|
0.81 [0.59, 1.12]
|
0.70 [0.49, 0.98]
|
Knee injury
|
4.05 [2.68, 6.11]
|
2.77 [1.96, 3.92]
|
2.63 [1.82, 3.78]
|
BMI/5
|
1.57 [1.30, 1.90]
|
1.90 [1.69, 2.14]
|
1.88 [1.66, 2.14]
|
Current smoking
|
0.86 [0.54, 1.37]
|
1.22 [0.76, 1.96]
|
1.12 [0.68, 1.86]
|
Current alcohol
|
1.40 [0.92, 2.14]
|
0.52 [0.29, 0.94]
|
0.57 [0.31, 1.07]
|
Current HRT
|
N/A
|
N/A
|
0.75 [0.48, 1.17]
|
Bilateral symptomatic knee OA
|
n = 943
|
n = 1,403
|
n = 1,172
|
Education (low)
|
0.90 [0.43, 1.88]
|
1.87 [1.13, 3.11]
|
1.84 [1.07, 3.16]
|
Physical activity (high)
|
0.81 [0.42, 1.60]
|
0.96 [0.61, 1.51]
|
0.97 [0.60, 1.57]
|
Occupation, PD
|
1.87 [0.86, 4.06]
|
0.84 [0.50, 1.39]
|
0.85 [0.49, 1.45]
|
Age 55-64
|
5.40 [1.68, 17.4]
|
3.40 [1.69, 6.85]
|
3.99 [1.64, 9.74]
|
Age 65-74
|
9.64 [3.03, 30.7]
|
5.10 [2.41, 10.8]
|
4.92 [1.91, 12.7]
|
Age 75 and over
|
16.9 [4.42, 64.5]
|
18.2 [7.92, 41.9]
|
16.8 [6.04, 46.6]
|
African American
|
1.13 [0.54, 2.37]
|
0.89 [0.56, 1.42]
|
0.81 [0.49, 1.33]
|
Knee Injury
|
2.19 [1.03, 4.65]
|
2.11 [1.26, 3.52]
|
1.79 [1.03, 3.12]
|
BMI/5
|
1.81 [1.31, 2.50]
|
2.20 [1.86, 2.60]
|
2.12 [1.76, 2.54]
|
Current smoking
|
0.77 [0.33, 1.77]
|
1.33 [0.65, 2.72]
|
1.23 [0.57, 2.68]
|
Current alcohol
|
1.51 [0.73, 3.14]
|
0.62 [0.26, 1.48]
|
0.78 [0.32, 1.89]
|
Current HRT
|
N/A
|
N/A
|
0.48 [0.22, 1.06]
|
-
Results are taken from the fully adjusted models as presented for education in Table 2
- PD, Physically Demanding (Occupation); Low educational attainment, <12 years; Occupationally related Physical Activity Score, high is ≥ 10 on a scale of 0-16 for lifting, standing, walking, and squatting.
- BMI/5 is the continuous, model variable; the OR represents an increase of 5 units of BMI.
- The referent class for age is 45-54 years.