Figure 3
From: New role for Agrin in T cells and its potential importance in immune system regulation
Schematic illustration showing a potential function for Agrin in the context of the immunological synapse. The organization of key surface receptors is illustrated in the context of the mature immunological synapse structure during antigen presentation or in the absence of stimulation. Agrin is shown in its fully glycosylated (no activation) and modified (activation) forms. Also shown is a hypothetical receptor for Agrin expressed by the antigen presenting cell (APC). ICAM, intracellular adhesion molecule; LFA, lymphocyte function-associated antigen; MHC, major histocompatibility complex.