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Table 4 Patients' clinical characteristics by disease category, cumulatively for the entire follow up period

From: Anticentromere antibody positive Sjögren's Syndrome: a retrospective descriptive analysis

Characteristics of patients
(P-value1)
ACA+/SS
(n = 20) [%]
SSc/(+) sicca
(n = 31) [%]
SSc/(-) sicca
(n = 20) [%]
ACA-/SS
(n = 61) [%]
Positive MSGB (0.039) 18 [94.7] 12 [75.0] - 54 [94.7]
P-values 2   0.156   1.000
Abnormal Rose Bengal (0.364) 8 [72.7] 9 [56.3] 0 [0.0] 22 [71.0]
P-values 2   0.448 0.333 1.000
Abnormal Schirmer test (0.176) 9 [64.3] 14 [87.5] 0 [0.0] 35.5 [71.4]
P-values 2   0.204 0.400 0.743
Abnormal BUT (0.428) 7 [77.8] 9 [75.0] 0 [0.0] 18 [69.2]
P-values 2   1.000 0.300 1.000
Lymphadenopathy (0,249) 3 [15.0] 8 [25.8] 1 [5.0] 9 [14.8]
P-values 2   0.493 0.605 1.000
Raynaud (<0.0001) 15 [75.0] 31 [100.0] 20 [100.0] 11 [18.0]
P-values 2   0.007 0.047 <0.0001
SGE (0.006) 3 [15.0] 4 [12.9] 0 [0.0] 20 [32.8]
P-values 2   1.000 0.231 0.160
Purpura (0,052) 2 [10.0] 1 [3.2] 0 [0.0] 11 [18.0]
P-values 2   0.553 0.487 0.502
Xerostomia (<0.0001) 19 [95.0] 25 [80.6] 0 [0.0] 53 [86.9]
P-values 2   0.223 <0.0001 0.440
Dry eyes (<0.0001) 17 [85.0] 29 [93.5] 0 [0.0] 60 [98.4]
P-values 2   0.369 <0.0001 0.045
Telangiectasias (<0.0001) 2 [10.0] 28 [90.3] 14 [70.0] 2 [3.3]
P-values 2   <0.0001 <0.0001 0.254
Puffy fingers (<0.0001) 7 [35.0] 26 [83.9] 14 [70.0] 10 [16.4]
P-values 2   0.001 0.056 0.112
Sclerodactyly (<0.0001) 0 [0.0] 31 [100.0] 19 [95.0] 0 [0.0]
P-values 2   <0.0001 <0.0001 -
Calcinosis (0. 001) 0 [0.0] 6 [19.4] 4 [20.0] 0 [0.0]
P-values 2   0.070 0.106 -
Ulcers (0.249) 2 [10.0] 17 [54.8] 11 [55.0] 0 [0.0]
P-values 2   0.001 0.006 0.059
Dysphagia (<0.0001) 7 [35.0] 18 [58.1] 5 [25.0] 4 [6.6]
P-values 2   0.153 0.731 0.004
GER (<0.0001) 3 [15.0] 20 [64.5] 10 [50.0] 6 [9.8]
P-values 2   0.001 0.041 0.682
Arthritits (0.372) 8 [35.0] 10 [32.3] 4 [20.0] 14 [23.0]
P-values 2   0.765 0.301 0.156
Dyspnoea (<0.0001) 7 [40.0] 20 [64.5] 5 [25.0] 9 [14.8]
P-values 2   0.049 0.731 0.060
PAH (0.004) 2 [10.0] 8 [25.8] 2 [10.0] 1 [1.6]
P-values 2   0.280 1.000 0.149
Ground glass HRCT (0.606) 0 [0.0] 4 [21.1] 1 [9.1] 1 [12.5]
P-values 2   0.544 1.000 1.000
Lung fibrosis (0.001) 2 [10.0] 12 [38.7] 7 [35.0] 5 [8.2]
P-values 2   0.029 0.127 1.000
Restrict. pattern PFTs (0.103) 2 [22.2] 8 [30.8] 6 [42.9] 0 [0.0]
P-values 2   1.000 0.400 0.211
Serositis (0.080) 3 [15.0] 6 [19.4] 3 [15.0] 2 [3.3]
P-values 2   1.000 0.019 0.094
Renal involvement (0.760) 0 [0.0] 0 [0.0] 0 [0.0] 1 [1.6]
P-values 2   - - 1.000
Carpal tunnel (0.853) 2 [10.0] 3 [9.7] 3 [15.0] 5 [4.9]
P-values 2   1.000 1.000 1.000
Per. Neuropathy (0.743) 1 [5.0] 2 [6.5] 0 [0.0] 3 [86.9]
P-values 2   1.000 1.000 1.000
Leucopenia (0,088) 2 [10.0] 2 [6.5] 2 [10.0] 15 [24.6]
P-values 2   0.640 1.000 0.216
Hypergammaglobulinaemia (0.0001) 5 [25.0] 6 [19.4] 1 [5.0] 31 [50.8]
P-values 2   0.732 0.182 0.068
Cryoglobulinaemia (0.609) 0 [0.0] 2 [6.5] 1 [5.0] 5 [4.9]
P-values 2   0.514 1.000 0.326
RF (0.015) 5 [25.0] 6 [19.4] 4 [20.0] 29 [47.5]
P-values 2   0.732 1.000 0.117
Low C3,C4 (0.289) 0 [0.0] 5 [20.0] 3 [23.1] 10 [19.6]
P-values 2   0.137 0.087 0.101
Proteinuria (0.760) 0 [0.0] 0 [0.0] 0 [0.0] 1 [1.6]
P-values 2   - - 1.000
  1. 1 Overall P-value from the Chi Square test of independence (significance < 0.05).
  2. 2 P-values from the Fisher's exact test comparing the first group with each of the other three groups MSGB: minor salivary gland biopsy, BUT, Tear film break up time, SGE, salivary gland enlargement, GER, gastroesophageal reflux, PAH, pulmonary arterial hypertension, HRCT, high resolution computed tomography, PFT, pulmonary function tests, RF, rheumatoid factor