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Table 1 Serum heterotrimer, BLyS, and APRIL levels in healthy donors, and patients with SLE or RA

From: B-lymphocyte stimulator/a proliferation-inducing ligand heterotrimers are elevated in the sera of patients with autoimmune disease and are neutralized by atacicept and B-cell maturation antigen-immunoglobulin

 

Heterotrimer

BLyS

APRIL

Patients

Number of samples with > LOQ

n/N(%)

Mean ± SDa

(ng/ml)

Number of samples with > LOQ

n/N(%)

Mean ± SDa

(ng/ml)

Number of samples with > LOQ

n/N(%)

Mean ± SDa

(ng/ml)

Healthy donors

7/89 (7.8)

0.83 ± 0.61

7/40 (17.5)

3.91 ± 3.47

1/39 (2.6)b

2.35 ± 0

SLE

24/89 (26.9)

0.52 ± 0.19

20/30 (66.7)

3.28 ± 2.35

11/29 (37.9)b

2.31 ± 0.18

RA

2/30 (6.7)

2.85 ± 3.55

10/30 (33.3)

8.07 ± 18.0

25/30 (83.3)

3.15 ± 1.44

  1. aMean concentration for serum samples with detectable ligand levels.
  2. bIn the subset of serum samples available, one sample from a healthy donor and one from a patient with SLE were not assayed because of insufficient volume.
  3. LOQ, limit of quantitation; RA, rheumatoid arthritis; SD, standard deviation; SLE, systemic lupus erythematosus.
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Arthritis Research & Therapy

ISSN: 1478-6362

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