Skip to main content

Table 1 Serum heterotrimer, BLyS, and APRIL levels in healthy donors, and patients with SLE or RA

From: B-lymphocyte stimulator/a proliferation-inducing ligand heterotrimers are elevated in the sera of patients with autoimmune disease and are neutralized by atacicept and B-cell maturation antigen-immunoglobulin

  Heterotrimer BLyS APRIL
Patients Number of samples with > LOQ
n/N(%)
Mean ± SDa
(ng/ml)
Number of samples with > LOQ
n/N(%)
Mean ± SDa
(ng/ml)
Number of samples with > LOQ
n/N(%)
Mean ± SDa
(ng/ml)
Healthy donors 7/89 (7.8) 0.83 ± 0.61 7/40 (17.5) 3.91 ± 3.47 1/39 (2.6)b 2.35 ± 0
SLE 24/89 (26.9) 0.52 ± 0.19 20/30 (66.7) 3.28 ± 2.35 11/29 (37.9)b 2.31 ± 0.18
RA 2/30 (6.7) 2.85 ± 3.55 10/30 (33.3) 8.07 ± 18.0 25/30 (83.3) 3.15 ± 1.44
  1. aMean concentration for serum samples with detectable ligand levels.
  2. bIn the subset of serum samples available, one sample from a healthy donor and one from a patient with SLE were not assayed because of insufficient volume.
  3. LOQ, limit of quantitation; RA, rheumatoid arthritis; SD, standard deviation; SLE, systemic lupus erythematosus.