Table 1 IL18 gene polymorphisms in a series of biopsy-proven GCA and matched controls

G/G

106 (50.0)

224 (55.6)

Reference

^-

G/C

94 (44.3)

159 (39.4)

0.20

1.25 (0.87-1.79)

C/C

12 (5.7)

20 (5.0)

0.53

1.27 (0.56-2.84)

G

306 (72.2)

607 (75.3)

Reference

^-

C

118 (27.8)

199 (24.7)

0.23

1.18 (0.89-1.55)

-607 (C->A) (rs1946518) ^a

Number = 212

Number = 405

P value

OR (95% CI)

C/C

53 (24.9)

129 (31.9)

Reference

^-

C/A

116 (54.7)

220 (54.3)

0.21

1.28 (0.85-1.94)

A/A

43 (20.4)

56 (13.8)

0.02

1.87 (1.09-3.21)

C

221 (52.2)

478 (59.1)

Reference

^-

A

203 (47.8)

332 (40.9)

0.02

1.32 (1.04-1.69)

-1297 (T->C) (rs360719) ^b

Number = 212

Number = 405

P value

OR (95% CI)

T/T

99 (46.7)

237 (58.5)

Reference

^-

T/C

96 (45.3)

150 (37.0)

0.02

1.53 (1.07-2.20)

C/C

17 (8.0)

18 (4.4)

0.02

2.26 (1.063-4.82)

T

294 (69.3)

624 (77.0)

Reference

^-

C

130 (30.7)

186 (23.0)

0.003

1.48 (1.13-1.95)