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Table 1 IL18 gene polymorphisms in a series of biopsy-proven GCA and matched controls

From: Association between IL-18gene polymorphisms and biopsy-proven giant cell arteritis

IL18
Polymorphisms
GCA patients
Number (%)
Healthy controls
Number (%)
  
-137 (G->C) (rs187238) Number = 212 Number = 403 Pvalue OR (95% CI)
G/G 106 (50.0) 224 (55.6) Reference -
G/C 94 (44.3) 159 (39.4) 0.20 1.25 (0.87-1.79)
C/C 12 (5.7) 20 (5.0) 0.53 1.27 (0.56-2.84)
G 306 (72.2) 607 (75.3) Reference -
C 118 (27.8) 199 (24.7) 0.23 1.18 (0.89-1.55)
-607 (C->A) (rs1946518) a Number = 212 Number = 405 P value OR (95% CI)
C/C 53 (24.9) 129 (31.9) Reference -
C/A 116 (54.7) 220 (54.3) 0.21 1.28 (0.85-1.94)
A/A 43 (20.4) 56 (13.8) 0.02 1.87 (1.09-3.21)
C 221 (52.2) 478 (59.1) Reference -
A 203 (47.8) 332 (40.9) 0.02 1.32 (1.04-1.69)
-1297 (T->C) (rs360719) b Number = 212 Number = 405 P value OR (95% CI)
T/T 99 (46.7) 237 (58.5) Reference -
T/C 96 (45.3) 150 (37.0) 0.02 1.53 (1.07-2.20)
C/C 17 (8.0) 18 (4.4) 0.02 2.26 (1.063-4.82)
T 294 (69.3) 624 (77.0) Reference -
C 130 (30.7) 186 (23.0) 0.003 1.48 (1.13-1.95)
  1. aGenotype distribution for the IL18 -607 (C->A) polymorphism: P = 0.054.
  2. bGenotype distribution for the IL18 -1297 (T->C) (rs360719): P = 0.011.
  3. Genotype frequencies for the IL18 -607 (C->A) (rs1946518) polymorphism: IL18 -607 A/A homozygous versus IL18 -607 C/A plus IL18 -607 C/C: P = 0.04; OR, 1.59; 95% CI, 1.02-2.46.
  4. Genotype frequencies for the IL18-1297 (T->C) (rs360719) polymorphism: IL18-1297 C/C plus IL18-1297 T/C genotypes compared to IL18-1297 T/T genotype: P = 0.005; OR, 1.61; 95% CI, 1.15-2.25.