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Table 1 Clinical, biochemical, immunological and immunohistological features of myositis patients

From: Myofiber stress-response in myositis: parallel investigations on patients and experimental animal models of muscle regeneration and systemic inflammation

Patient Sex Disease duration (months) Muscle weakness DM skin rash Serum CPKa (U/l) EMGb ANA (IF)b Specific autoantibodies Muscle biopsyc
          Inflammation (site of biopsy) Immunoreactivity for
           MHC-I εMy (% of total)
Group I            
   1 F 4 P A 5027 + - Jo-1, RoSSA ++ (VL) ++ 36.60
   2 F 15 P A 8570 + - Jo-1 ++ (D) ++ 35.50
   3 F 8 P A 2762 - + Jo-1, RoSSA ++ (VL) + 15.50
   4 F 168 P A 1100 + - - ++ (VL) ++ 1.09
   5 M 29 P A 1125 - + Mi-2 ++ (VL) + 0.33
   6 F 13 P P 292 + - - ++ (VL) ++ 0
   7 F 3 P A 6705 + - Jo-1 + (VL) + 7.79
   8 F 25 A A 1840 + + tRNA, RoSSA + (VL) ++ 2.00
   9 M 25 P P 484 + - Mi-2 + (D) ++ 6.00
   10 M 79 P A 535 - + U1RNP, RoSSA + (VL) ++ 36.60
   11 F 9 P A 2762 + + - + (VL) + 15.55
   12 F 13 P A 666 + - - + (TA) ++ 3.10
   13 M 36 P A 2580 - + tRNA + (VL) + 0.20
   14 F 103 P A 893 + + Jo-1 + (VL) + 0.06
Group II            
   15 F 27 P A 173 - + Jo-1 - (VL) + 0.13
   16 M 72 P A 548 - - - - (VL) + 0
   17 F 79 P A < 160 - + Ro/SSA - (D) ++ 0
   18 M 33 P P 600 ND + - - (D) ++ 0.42
   19 F 21 P A 221 + + Scl70, Ku - (VL) ++ 2.60
   20 F 180 P A 1157 + + Jo-1 - (VL) + 0
   21 F 67 P A 533 + + Mitotic apparatus - (D) + 1.1
Group III            
   22 F 237 P A 450 - - - - (VL) - 0.50
   23 F 58 P A 43 + - - - (VL) - 0
   24 F 237 P A 742 + - - - (D) - 0
   25 M 24 P A 250 - - - - (VL) - 0
   26 F 15 P A 1600 - - - - (VL) - 1.11
   27 F 68 P A 628 + - - - (VL) - 0
   28 M 33 P P 9868 + - - - (VL) - 0
   29 F 24 P P 254 - + - - (VL) - 0
  1. aValues correspond to those obtained at the time of muscle biopsy. b+ and -, presence and absence of positive response, respectively. c+ and ++, degree of inflammation and MHC-I immunofluorescence, evaluated as described in Materials and methods; -, absence. DM, dermatomyositis; CPK, creatine phosphokinase; EMG, electromyography; ANA (IF), antinuclear antibodies (immunofluorescence); MHC-I: class I major histocompatibility complex antigen; εMy (% of total), percentage of myofibers positive for embryonic skeletal myosin on total biopsy fibers; F, female; M, male; P, present; A, absent; VL, vastus lateralis muscle; D, deltoid muscle; TA, tibialis anterior muscle; ND, not done.