Figure 3

The frequency of IL-17⁺ CD4⁺ T cells correlates with disease activity. (a-c) Relation between SLEDAI score and the frequency (%) of (a) CD4⁺IL-17⁺ T cells, (b) CD4⁺IL-17⁺IFN-γ⁺ T cells and (d) CD4⁺IFN-γ⁺ T cells in patients with SLE (n = 25). (d) Dot plots showing the frequency of CD4⁺ T cells producing IL-17 and/or IFN-γ in a patients with SLE at the times of high and low disease activities (SLEDAI score, 16 and 6, respectively). Representative data from two patients with SLE. (e) The frequency of CD4⁺IL-17⁺ T cells in patients with (+, n = 11) and without (-, n = 14) lupus nephritis. Numbers in dot plots indicate the frequency of cells for each quadrant. Bars show the means.