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Table 2 Genes differentially expressed in osteoarthritis meniscal cells compared with normal control cells

From: Calcium deposition in osteoarthritic meniscus and meniscal cell culture

Gene name Gene ID Real-time RT-PCRa Differential gene expressionb (fold) Description
    OA1 OA2 OA3 OA4 OA5  
ENPP1 BF057080 2.1 1.7 2.0 2.8 1.9 2.0 Ectonucleotide pyrophosphatase 1
ANKH AL833238 1.9 2.4 1.8 1.7 1.5 1.8 Ankylosis, progressive homolog
MGP NM_000900 5.3 11.8 4.7 21.6 0 17.6 Matrix Gla protein
SRGN NM_002727 3.3 2.2 3.1 8.3 3.1 1.9 Serglycin
  1. aThe ratio of the relative expression level of a specific gene in osteoarthritis (OA) meniscal cells derived from five OA patients (RNA mixture) to the relative expression level of the specific gene in the control meniscal cells derived from three normal control subjects (RNA mixture), which were determined by real-time RT-PCR analysis with P < 0.01. bMicroarray analysis of the differential expression of a specific gene in the individual OA cells derived from five different OA patients compared with three normal control meniscal cells as a group. OA1, derived from a 65-year-old female OA patient; OA2, derived from a 56-year-old female OA patient; OA3, derived from a 50-year-old female OA patient; OA4, derived from a 52-year-old female OA patient; OA5, derived from a 61-year-old male OA patient; Normal 1, derived from a 36-year-old female osteosarcoma patient; Normal 2, derived from a 43-year-old female osteosarcoma patient; Normal 3, derived from a 12-year-old female osteosarcoma patient. Microarray analyses were carried out as described in Materials and methods. The raw microarray data can be found in the Gene Expression Omnibus [GEO:GSE19060] [49].