Skip to main content

Advertisement

Table 2 Genotype frequencies in rheumatoid arthritis, and in autoantibody-positive/autoantibody-negative rheumatoid arthritis, relative to controls

From: Evaluation of the rheumatoid arthritis susceptibility loci HLA-DRB1, PTPN22, OLIG3/TNFAIP3, STAT4 and TRAF1/C5 in an inception cohort

RA cohort Controls, n(%) Cases, n(%) Per-allele OR (95% CI) P trend Autoantibody-positive RA Per-allele OR (95% CI) P trend Autoantibody-negative RA Per-allele OR (95% CI) P trend
HLA-DRB1 shared epitope n = 1,351 n = 968    n = 643    n = 298   
   Negative 717 (53.1) 290 (30.0)    138 (21.5)    144 (48.3)   
   One copy 517 (38.3) 475 (49.1) 2.12 (1.87 to 2.40) <0.0001 332 (51.6) 2.85 (2.46 to 3.29) <0.0001 129 (43.3) 1.11 (0.92 to 1.35) 0.279
   Two copies 117 (8.7) 203 (21.0)    173 (26.9)    25 (8.4)   
PTPN22 (rs2476601) n = 3,492 n = 855    n = 572    n = 259   
   GG 2,817 (80.7) 624 (73.0)    413 (72.2)    195 (75.3)   
   GA 635 (18.2) 212 (24.8) 1.50 (1.28 to 1.75) <0.0001 144 (25.2) 1.56 (1.31 to 1.87) <0.0001 60 (23.2) 1.32 (1.01 to 1.72) 0.039
   AA 40 (1.1) 19 (2.2)    15 (2.6)    4 (1.5)   
OLIG3/TNFAIP3 (rs6920220) n = 3,478 n = 810    n = 545    n = 242   
   GG 2,146 (61.7) 464 (57.3)    294 (53.9)    155 (64.0)   
   GA 1,197 (34.4) 303 (37.4) 1.19 (1.04 to 1.35) 0.009 220 (40.4) 1.32 (1.14 to 1.54) <0.0001 77 (31.8) 0.94 (0.74 to 1.18) 0.578
   AA 135 (3.9) 43 (5.3)    31 (5.7)    10 (4.1)   
STAT4 (rs7574865) n = 3,520 n = 767    n = 515    n = 234   
   GG 2,151 (61.1) 451 (58.8)    294 (57.1)    143 (61.1)   
   GT 1,208 (34.3) 264 (34.4) 1.14 (1.00 to 1.29) 0.054 190 (36.9) 1.17 (1.00 to 1.36) 0.048 70 (29.9) 1.13 (0.91 to 1.41) 0.266
   TT 161 (4.6) 52 (6.8)    31 (6.0)    21 (9.0)   
TRAF1/C5 (rs10760130) n = 3,506 n = 763    n = 512    n = 233   
   AA 1,096 (31.3) 224 (29.4)    151 (29.5)    69 (29.6)   
   GA 1,742 (49.7) 363 (47.6) 1.13 (1.01 to 1.26) 0.035 238 (46.5) 1.15 (1.00 to 1.31) 0.043 114 (48.9) 1.09 (0.90 to 1.31) 0.392
   GG 668 (19.1) 176 (23.1)    123 (24.0)    50 (21.5)   
  1. CI, confidence interval; OR, odds ratio; RA, rheumatoid arthritis.