Table 2 Genotype frequencies in rheumatoid arthritis, and in autoantibody-positive/autoantibody-negative rheumatoid arthritis, relative to controls

HLA-DRB1 shared epitope

n = 1,351

n = 968

n = 643

n = 298

   Negative

717 (53.1)

290 (30.0)

138 (21.5)

144 (48.3)

   One copy

517 (38.3)

475 (49.1)

2.12 (1.87 to 2.40)

<0.0001

332 (51.6)

2.85 (2.46 to 3.29)

<0.0001

129 (43.3)

1.11 (0.92 to 1.35)

0.279

   Two copies

117 (8.7)

203 (21.0)

173 (26.9)

25 (8.4)

PTPN22 (rs2476601)

n = 3,492

n = 855

n = 572

n = 259

   GG

2,817 (80.7)

624 (73.0)

413 (72.2)

195 (75.3)

   GA

635 (18.2)

212 (24.8)

1.50 (1.28 to 1.75)

<0.0001

144 (25.2)

1.56 (1.31 to 1.87)

<0.0001

60 (23.2)

1.32 (1.01 to 1.72)

0.039

   AA

40 (1.1)

19 (2.2)

15 (2.6)

4 (1.5)

OLIG3/TNFAIP3 (rs6920220)

n = 3,478

n = 810

n = 545

n = 242

   GG

2,146 (61.7)

464 (57.3)

294 (53.9)

155 (64.0)

   GA

1,197 (34.4)

303 (37.4)

1.19 (1.04 to 1.35)

0.009

220 (40.4)

1.32 (1.14 to 1.54)

<0.0001

77 (31.8)

0.94 (0.74 to 1.18)

0.578

   AA

135 (3.9)

43 (5.3)

31 (5.7)

10 (4.1)

STAT4 (rs7574865)

n = 3,520

n = 767

n = 515

n = 234

   GG

2,151 (61.1)

451 (58.8)

294 (57.1)

143 (61.1)

   GT

1,208 (34.3)

264 (34.4)

1.14 (1.00 to 1.29)

0.054

190 (36.9)

1.17 (1.00 to 1.36)

0.048

70 (29.9)

1.13 (0.91 to 1.41)

0.266

   TT

161 (4.6)

52 (6.8)

31 (6.0)

21 (9.0)

TRAF1/C5 (rs10760130)

n = 3,506

n = 763

n = 512

n = 233

   AA

1,096 (31.3)

224 (29.4)

151 (29.5)

69 (29.6)

   GA

1,742 (49.7)

363 (47.6)

1.13 (1.01 to 1.26)

0.035

238 (46.5)

1.15 (1.00 to 1.31)

0.043

114 (48.9)

1.09 (0.90 to 1.31)

0.392

   GG

668 (19.1)

176 (23.1)

123 (24.0)

50 (21.5)